east2west

19 ms·

121.
by east2west 14y ago
No kidding about reinventing wheels. I once saw a manuscript based entirely on dot-product as 1-D least-square. I don't know what happened to it, but one reviewer called it a seminal event in GWAS. Bioinformatics is hard, but too many caree
122.
by east2west 14y ago
Well, I can call myself a bioinformatics researcher, I guess, as I have CS Ph.D working in genetics/genomics. I see your point of throwing computers at simple solutions as cheaper than throwing good programmers. I do that too. We are very f
123.
by east2west 14y ago
Well, considering that Amgen could only reproduce 11% of "landmark" papers in cancer research, peer review is missing a lot. See "Drug development: Raise standards for preclinical cancer research" http://www.nature.com/nature/journal/v483/
124.
by east2west 14y ago
I don't want to get into a pissing contest but just to point out there are people equal of him in the versatility and greatness, such as his great rival Michelangelo, who is also a great sculptor and great architect. Da Vinci's work as a fi
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by east2west 14y ago
I don't see such a sharp divergence as a computer science major working in a top statistics department. Statistics does not magically work well in hard sciences and machine learning has worked very well in many fields. I don't know if you c
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by east2west 14y ago
You make it sound like MMA is better than Matlab for even numerical work. Is this true? For example, would machine learning algorithms be better code in MMA than Matlab? Matlab right now dominates engineering and in particular machine learn
127.
by east2west 14y ago
I wonder how this will impact air travel. It is a real shame that after Concord retired there is no supersonic jetliner in service, which at least kept the dream alive even if Concord is expensive and short legged. I believe no viable progr
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by east2west 14y ago
I won't have time to read big books in foreseeable future, especially if they are not related to my core research areas. But I will try this and see what I can get out of it.
129.
by east2west 14y ago
All good advice. Right now I only write out major tasks and outlines of procedures to achieve them. Maybe I first should abstract out core data structures and operations on them. I will try that.
130.
by east2west 14y ago
This brings up a burning question that I have been pondering for a while. I still don't get how to properly design good APIs. I have been programming but as a scientific research not as a professional developer, and I have found I cannot re
131.
Fighting about ENCODE and junk(blogs.nature.com)
1 points by east2west 14y ago|0 comments
132.
by east2west 14y ago
DO NOT EVER use Penrose pseudoinverse in numerical computation. It is guaranteed to diverge.
133.
by east2west 14y ago
Someone once said that all models are wrong, but some are more useful than others (paraphrasing).
134.
by east2west 14y ago
I am an indirect member of modENCODE project -- I am paid by the project but work on computational and data analysis and therefore not wed to it. I feel I should clear up a few things. First, that 80% figure is a guesstimate, far from defin
135.
by east2west 14y ago
If you knew how they found the elements together, you would be far less sanguine about the significance. They started with random sampling of close proximity of genomic positions, plus some basic structural info on how chromatins (coiled DN
136.
by east2west 14y ago
This is the reality of biomedical research today. With NIH funding level flatlining in recent years and congress leery of more spending in anything other than military, medical utility is the mantra now within NIH. The irony is that most of
137.
by east2west 15y ago
>I couldn't disagree more. As an example, linear algebra is something >that has been bothering me for years, long after my college math >courses. One of its central topics is eigenvectors and eigenvalues. >Every textbook I c
138.
by east2west 15y ago
I don't understand. This kind of sentences is routine in New York Times. If anything, I find the conversational tone inappropriate for such a weighty subject. I do agree that the author tried too hard to write to a broader audience on a com