cthalupa

45 ms·

601.
by cthalupa 2y ago
Yes, but you would certainly still see some - it's just a consequence of weight loss. Even IFBB bodybuilders on god knows how many steroids see some muscle loss when cutting. Eat a whole lot of protein, lift, and you're going to b
602.
by cthalupa 2y ago
There is some evidence to suggest that vitamin d supplementation can result in increased calcification of arteries: https://pubmed.ncbi.nlm.nih.gov/26995293/ https://www.ncbi.nlm.nih.gov/pmc/articl
603.
by cthalupa 2y ago
> By the way - why are you so eager to promote this drug - can you please declare any conflict of interests? The closest thing to a conflict of interest I have is that I am currently seeing great results while taking tirzepatide. I find
604.
by cthalupa 2y ago
You're still not providing any sort of claim as to what actual negative side effects you are concerned about, so I don't really know how to have a serious conversation with you. "Interfering with cellular metabolism" is
605.
by cthalupa 2y ago
Exercise is good for a variety of reasons. It will burn some additional calories. But most scientists that specialize in metabolic research believe that the constrained total energy expenditure model and metabolic adaption are at least broa
606.
by cthalupa 2y ago
Supra-physiological levels of testosterone and steroids have incredibly well known and well researched short, medium, and long term side effects. They've been well known for forever. In an alternate world where steroids had a good safe
607.
by cthalupa 2y ago
We know obesity is one of the absolute worst things you can do to yourself as a human. We know that being prescribed diet and exercise has not helped hundreds of millions of people in the world stop being obese. We do not catch every long t
608.
by cthalupa 2y ago
> In contrast with the huge amount of money that the pharma industry spends in marketing GLP1 drugs to people Drugs lose their patents and much of the research on novel medications is done in partnerships with universities, etc. Plenty o
609.
by cthalupa 2y ago
It's simply not true that this trend isn't impacting other countries. Mexico is only 6% behind the US. The UK is 16%. Obesity is rising rapidly in South Korea - more than doubled in adult males between 2009 and 2019. America pione
610.
by cthalupa 2y ago
We know for sure that obesity is one of the single biggest increases in all-cause mortality. We know it is directly linked to most of the top disease-related causes of death. > But we do know that diet and exercise work. Do you think the
611.
by cthalupa 2y ago
Obesity is rising rapidly over much of the developed world, both in Europe and Asia, on a trajectory fairly similar to the historical trajectory of it in the US. Obesity in adult men in North Korea more than doubled between 2009 and 2019. T
612.
by cthalupa 2y ago
Sure. You're going to lose some muscle mass no matter what you do. And yeah, if you don't do either of those things, you're going to lose even more. But fat people actually frequently have quite a bit of lean body mass - it t
613.
by cthalupa 2y ago
I'll start with stating that Joe Rogan has, as the years have gone on, resulted to more and more fringe guests on basically every subject. Then I'll point out that these guests are MDs, not PhDs. And then I'll point out this
614.
by cthalupa 2y ago
> Here I am looking from western Europe at 100% self-inflicted US obesity epidemics and shaking my head in disbelief, what kind of garbage and in what massive quantities you guys consume daily. 26% and climbing in the UK. 19% and climbin
615.
by cthalupa 2y ago
The GI issues tend to be minor. Unpleasant, but not exactly any more debilitating than a lactose intolerant person deciding that they really really wanted that extra large milkshake. Some people have it worse - but those, to my understandin
616.
by cthalupa 2y ago
It's possible. But, we've had another GLP-1 medication in use for about a decade and a half now - liraglutide. So far, we haven't seen evidence of that occurring. I don't think anyone who is both informed and sane would
617.
by cthalupa 2y ago
That's the danger of any rapid weight loss where you don't exercise and ingest additional protein. I knew about it from prior research, but my doctor made sure to mention it to me as well. He's also monitoring the speed of my
618.
by cthalupa 2y ago
Probably more or less the same as to what happens with skinny people who have a garbage diet but just eat less or have significantly higher metabolisms. It's not great. The good news is it's quite commonly reported (and I can add
619.
by cthalupa 2y ago
Sure. But what's the proposed mechanism? For many - not all, obviously - medications, we have an understanding of potential long term risks. Animal studies catch some of them, others we know are potentially risky even without animal st
620.
by cthalupa 2y ago
Yes, it is within the realm of human power for every individual to not be obese. But the fact of the matter is... a huge chunk of people don't succeed. 42% of American adults are obese. "Eat better and exercise" has not resol
621.
by cthalupa 2y ago
It's well established science that chemical reactions, hormones, etc. in the body 100% influence your hunger and cravings. That doesn't mean that it's not within the means of human willpower to overcome it - everyone has the
622.
by cthalupa 2y ago
What's the explanation for why GLP1 medications are negative things? There are a very minor subset of people that have some medically significant adverse reactions, but it is VERY small. We don't have any evidence to my knowledge
623.
by cthalupa 2y ago
Cagrilintide (paired with semaglutide) and retatrutide are the next wave, though I'm not aware of any research for either indicating an increase in muscle mass. My understanding of the literature is that there's nothing special ab
624.
by cthalupa 2y ago
I'm someone that has spent many years of my life eating well and exercising regularly, including weightlifting. I'm also someone who has spent the past decade doing neither of those things, with one attempt in the middle to correc
625.
by cthalupa 2y ago
> Powerlifters at that level is on gear. Lots are. Lots aren't. There are a variety of leagues and federations that test frequently, both in-competition and out of season. We know they're almost certainly keeping these clan bec
626.
by cthalupa 2y ago
> but 3-5 sets of 10 exercises from 60% - 80% seems to be a hypertrophy program than strength. 10 rep range still provides plenty of strength gains as long as you are pushing to near failure. It is less CNS adaptation than going much nea
627.
by cthalupa 2y ago
This has been my experience with a sustained period over years of lifting in my early to mid 20s and several periods of restarting since then. Even when regularly adding weight, after a few months I stopped being particularly sore. I could
628.
by cthalupa 2y ago
> However, given proper programming, cardio has better benefit for longevity than strength. It's not that simple. For example, there is evidence that cardio does not impact pericardial adipose tissue mass, while resistance training
629.
by cthalupa 2y ago
> It really doesn't matter whether you do 5 reps or 20 As long as you're training to the point that you are getting close to failure and you don't have efficiency in one particular area in mind, sure. >as if magically y
630.
by cthalupa 2y ago
There are plenty of ways to injure yourself on machines. There are some specific dangers to free weights that aren't there with machines, e.g. if you are bench pressing outside a rack and you drop the weight on your throat, that's

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