cthalupa

29 ms·

511.
by cthalupa 2y ago
Most data on HMB shows that it is effective in preserving muscle mass in people with cancer cachexia or the eldery, results are generally not great for those without specific diseases or of younger age. I'm still taking it because it&#
512.
by cthalupa 2y ago
Fruits, yes, because it will kick you out of ketosis. Fiber, every keto adherent I knew would eat fiber in reasonably large quantities because keto often causes constipation, and a lot of the substitutes for things with "regular"
513.
by cthalupa 2y ago
Natural bodybuilders 100% go through bulking and cutting cycles. Outside of noob gains it is incredibly difficult for a natural to add muscle mass when in a calorie deficit and recomposition at maintenance calories is also inefficient in th
514.
by cthalupa 2y ago
The two meta-analysis are interesting, I think. https://www.liebertpub.com/doi/abs/10.1089/thy.2023.0530 > Overall there is no conclusive evidence of elevated thyroid cancer risk. https://dom-pu
515.
by cthalupa 2y ago
There is a dosing schedule for all the GLP-1s, with what is considered the minimal therapeutic dose being several times your initial dose. However, a lot of people either see results on these initial doses, and plenty of people find them to
516.
by cthalupa 2y ago
There are more and more PhD researchers focusing on resistance training these days, and yeah, it turns out the minimum effective dose is waaaaaay lower than we previously thought. https://www.minimumdosetraining.com/ - free
517.
by cthalupa 2y ago
Your position does not match that of medical researchers. https://jamanetwork.com/journals/jama/fullarticle/2810542 https://pmc.ncbi.nlm.nih.gov/articles/PMC10874596/ https:/&
518.
by cthalupa 2y ago
A good portion of the strength related to any specific lift is CNS adaptation up until a certain point (and most new lifters won't hit that threshold for quite some time), so strength on a lift you've been doing regularly isn&#x27
519.
by cthalupa 2y ago
> digestive problems where food rots in your stomach I assume you mean gastroparesis - this is an extremely rare side effect > Bad depression Again, pretty rare side effect. If you think these are the minor things I'm confused
520.
by cthalupa 2y ago
I'm sure there are plenty of people taking it as a shortcut to dropping 10 or 20lb or whatever, but I imagine most people taking it are in the "I need to lose 70+ lb of fat" range.
521.
by cthalupa 2y ago
Well, lots of people back off those dosages once they reach their goal weight and have minimal difficulty maintaining. As we know more about the long term effects of staying on the drug, it's totally possible it might make sense just t
522.
by cthalupa 2y ago
I've seen it happen with people even prior to the GLP-1s - prior to an injury derailing my last attempt to lose weight, I lost 30lb at an even faster rate and had 3 DEXA scans showing consistent increases in LBM. This conversation does
523.
by cthalupa 2y ago
China. It's trivial to purchase retatrutide, semaglutide, tirzepatide, and a wide variety of other peptides from Chinese labs, and for pennies on the dollar compared even to compounding pharmacy prices.
524.
by cthalupa 2y ago
Semaglutide is a 3rd generation GLP-1 agonist, though. We're 20 years in on GLP-1s at this point.
525.
by cthalupa 2y ago
Just the former is likely enough over a 6 month span, even without great genetics. That's only a 1.6lb/week loss. Noob gains can be huge.
526.
by cthalupa 2y ago
> but we did not see increased heart disease in human RCTs of these drugs. In fact, we've even seen the opposite - that it's cardioprotective.
527.
by cthalupa 2y ago
I find it significantly easier to eat healthy on tirzepatide, fwiw.
528.
by cthalupa 2y ago
https://macrofactorapp.com/body-composition/ Estimates in level of inaccuracy on the high end ranges from ~5% to ~10% If you see your lean mass going up in DEXA, your muscles are getting larger, and you're getting
529.
by cthalupa 2y ago
I am getting regular DEXA scans
530.
by cthalupa 2y ago
Well, these studies look at FFM, which does include your water weight and glycogen stores, so they do make up a portion of it.
531.
by cthalupa 2y ago
Even pros on high doses of testosterone and multiple AAS lose some muscle mass when preparing for a show.
532.
by cthalupa 2y ago
I'm someone that used to be fit and lifted regularly. Got busy, got lazy, got fat. Tried multiple times to get not-fat after getting fat, and found it to be too difficult for me, despite it not being something I struggled with for many
533.
by cthalupa 2y ago
If you are outside of your noob gains period and keep up your protein intake and resistance training you will minimize your muscle loss, but you'll still see some. Bodybuilders will even take AAS that explicitly reduce catabolism of mu
534.
by cthalupa 2y ago
Well, bulking and cutting cycles are pretty common for anyone beyond the beginniner stage when wanting to add muscle mass, even if they're more recreational or a powerlifter or whatever. It's just way more efficient to be in a lar
535.
by cthalupa 2y ago
So, yes and no. If you're doing resistance training for the first time in your life or the first time in years, noob gains will outpace loss if you train hard and get adequate protein. This is the case for a lot of people on these GLP-
536.
by cthalupa 2y ago
Yep. I started resistance training 5x a week about a month in on tirzepatide and even with a severely restricted caloric intake (I just can't eat enough), I've gained LBM.
537.
by cthalupa 2y ago
Water weight is a big one, and is part of your FFM. I lost 10lb of water weight in my first 24 hours on tirzepatide. Some of it is likely bone density as well. You can prevent the bone density and muscle loss with proper diet and exercise,
538.
by cthalupa 2y ago
It's basically a bottom shelf amaro. If you like amaros, you can probably find malort palatable. But bitterness is a very divisive flavor so lots of people just have extreme reactions to amaros in general and malort in particular.
539.
by cthalupa 2y ago
Elena Branson donated to one politician in her time as a Russian asset in the US: Gabbard. We know that Branson was in contact with a Representative as part of her unregistered agent activities, though it was never officially confirmed to b
540.
by cthalupa 2y ago
https://www.popsci.com/environment/meta-nuclear-power-bee/ It looks like the specific nuclear plant and bee species haven't been named. PopSci interviewed a Purdue professor and got a few guesses from him - s

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