cthalupa

27 ms·

451.
by cthalupa 2y ago
This is likely just from losing weight rapidly in general. We see it with people losing weight from a variety of other sources, too. It's possible GLP-1s might enhance the effect in some way, but it's already a significant enough
452.
by cthalupa 2y ago
Muscle actually is an intervention for one of the biggest risk factors in metabolic syndrome - insulin resistance. Muscles use glycogen. They use more glycogen when you're doing the sort of thing that builds muscle, so of course it&#x2
453.
by cthalupa 2y ago
Yeah, LVH is the big deal there in both cases. Telmisartan, an ARB generally used for BP management, can actually reverse LVH to a significant degree over time, though. Popular for bodybuilders on large quantities of AAS for that reason.
454.
by cthalupa 2y ago
If we didn't see tons of people reaching their "target weight" on GLP-1 drugs while having unhealthily low levels of lean body mass, you might have a point. But that is what we do see. I'd argue that they're still i
455.
by cthalupa 2y ago
The idea that people on GLP-1s shouldn't be trying to preserve (or indeed build) as much muscle mass as they can is absurd. It is more important than ever to perform resistance training and make sure you are getting adequate protein. B
456.
by cthalupa 2y ago
This is one of those statements that is technically true but not particularly relevant. Obese people are almost never at a level of lean body mass that they would overall be at a good amount of muscle even for a healthy total weight, and ra
457.
by cthalupa 2y ago
The problem is it is bad. People aren't just losing a proportional amount of muscle to fat mass to keep a good ratio - rapid weight loss is more catabolic towards lean body mass than it is with slower weight loss. And most obese peop
458.
by cthalupa 2y ago
This is silly. I'm a big proponent of GLP-1s (and on one!) but we can and do see people on these reaching sarcopenic levels of lean body mass. The overwhelming majority of people on these drugs should absolutely be doing everything the
459.
by cthalupa 2y ago
No. We are explicitly talking about a mandate - the will of the median voter. Someone who did not receive even half of the popular vote is not representative of the median voter. Just winning is not enough to receive a mandate.
460.
by cthalupa 2y ago
This all has me quite torn. The "smart" features on it are genuinely useful for me - I have sleep apnea, as well as an eight sleep + the electronic platform. It automatically changes the elevation of my head based on apnea events,
461.
by cthalupa 2y ago
The newer models have a touch control panel on the side. Different taps to adjust settings. Not that this ameliorates all the other issues here.
462.
by cthalupa 2y ago
Then why do we have different levels of security clearance? Obviously we have an extensive framework for data security within the government that is built upon the idea that compartmentalization of data and limiting access is incredibly imp
463.
by cthalupa 2y ago
> If it does not have a mandate, neither of the previous administrations did. I would agree with this. I think the last time an administration had a clear mandate was Obama's first term. Every election since then the margin has been
464.
by cthalupa 2y ago
I didn't say he wasn't elected. I said he didn't have a mandate. If he did not secure even half of the popular vote then it is obvious that the median voter does not align with his views.
465.
by cthalupa 2y ago
Trump didn't even get half the popular vote. That's not a mandate.
466.
by cthalupa 2y ago
A wide variety of joint issues are improved by performing a slow and steady progressive overload with lifting weights. Not all of them, of course, and yes there are some issues that preclude lifting, but this seems rather pedantic. There ar
467.
by cthalupa 2y ago
For the overwhelming majority of people just becoming a permanent resident is more than enough - there's not a strong need to become a Japanese citizen vs. permanent residency outside of the right to vote, and for overwhelming majority
468.
by cthalupa 2y ago
Do you think that physical violence is the only sort of thing that police can unjustly inflict upon you? I love Japan, have spent a significant quantity of time there, and if I was a billionaire, it'd be the place where I bought the pe
469.
by cthalupa 2y ago
If you think there's not plenty of trash strewn about, you need to spend more time out at night or down back alleys. Once the booze starts flowing or the kitchens get too busy, plenty of waste starts appearing. You're less likely
470.
by cthalupa 2y ago
Walk off the main thoroughfares of Tokyo and you end up with plenty of grunge and grime, too. I got invited to step outside for a cigarette at a craft beer joint down an alley in Shibuya and our 3rd companion was a rat as large as any I&#x2
471.
by cthalupa 2y ago
This was... always, the case though? For any CDN service? How do you serve traffic to people without knowing where to send it?
472.
by cthalupa 2y ago
You can almost certainly narrow down the McDonalds with a wide variety of things - this example is fairly contrived. If you can see outside of the McDonalds for street view to be usable, you're almost certainly able to determine what c
473.
by cthalupa 2y ago
I don't really care about either of them - people can eat what they want, it doesn't effect me any. But vegans of European descent are, from my anecdotal experience, the most likely to moralize towards me on the atrocities I am co
474.
by cthalupa 2y ago
Yeah - I would have liked Falme to be more epic, and Tarwin's Gap/Rand's fight with Aginor/Ishamael in Eye of the World. Impressive CGI is apparently quite expensive, though, especially at the scale necessary to really d
475.
by cthalupa 2y ago
For sure. I've also learned that some people just... didn't read the books all that closely, either. Or at least not character descriptions. Two Rivers people are described as being dark eyed and dark haired with fairly dark compl
476.
by cthalupa 2y ago
Yeah. His storyline was supposed to track the original series much more closely, but filming got shut down for covid, and the actor didn't come back when it resumed. Deleted all his socials, etc. Didn't take any more work until ju
477.
by cthalupa 2y ago
There's no world where anyone adapts the book series closely with live action. The series is simply too long, particularly for the level of CGI, etc., we expect out of this sort of "premiere" television. I think overall they&
478.
by cthalupa 2y ago
I'd consider myself a WoT megafan. I've read the full series more than 10 times since AMoL, and did a re-read of the series before every book release when it was being written. I'm in the middle of a re-read right now, even -
479.
by cthalupa 2y ago
I'm up to roughly 40 boards at this point. I use two of them basically daily - my desktop and laptop dock. I tend to rotate them a few times a month. The hobby is about the gear, but the people that get really deep into it tend to be b
480.
by cthalupa 2y ago
There's a bit wrong on the keycap material side of things. You can't directly compare ABS to PBT in a vacuum - different specific blends of both are used in keycaps, for various price points/purposes/etc. There's al

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