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cthalupa
searching PlanetScale…
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31 ms
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301.
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by
cthalupa
11mo ago
I think there is very little our founding fathers would recognize about today's american government, in a wide variety of ways. Jefferson was probably the least myopic among them, in at least recognizing that all humans are myopic and
302.
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cthalupa
11mo ago
More than a decade later, the GOP has still yet to present an alternative healthcare plan to the ACA. Actual leftists have continued to push and argue for a true single payer system. The ACA Is far from perfect but it was a significant step
303.
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cthalupa
11mo ago
> I have friends who smoke and have seen over the years how they've abandoned hobbies in favor of smoking more. Where's the outrage about that? Why in the world would I or anyone else have any right to be outraged over someone
304.
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cthalupa
11mo ago
Legal weed senators were voting for it because their constituents include people growing legal weed. The hemp product market competes with these constituents. The anti-weed senators were voting for it because they are anti-weed.
305.
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cthalupa
11mo ago
The filibuster is not a feature inherent to the Senate and could be removed at any time with a simple majority, just like it has been done for the filibuster for several types of nominations, and was threatened during this past shutdown. I
306.
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cthalupa
11mo ago
And so was the Permanent Apportionment Act. Revoke them both and we're much closer to what the founders intended when it comes to Congress.
307.
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cthalupa
11mo ago
They might have envisioned it during their lifetimes, but I don't see how you can argue that things that happened after the Constitution/BoR were written informed their decisions while writing it.
308.
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cthalupa
11mo ago
Intended to, but due to the Permanent Apportionment Act, does not do so in actuality. Congress is currently structured so that both chambers provide outsized representation to lower population states. With how the electoral college works, t
309.
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cthalupa
11mo ago
> The House represents the people and that already has the proportional representation you are seeking. It explicitly does not due to Permanent Apportionment Act. It is more proportional than the senate, but the hard cap on the size of t
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cthalupa
11mo ago
The problem with this argument is the Permanent Apportionment Act. The House is more representative of the people than the Senate, but capping the size means that as it stands lower population states still receive an outsized amount of powe
311.
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cthalupa
11mo ago
The FDA errs on the side of placing more warnings rather than fewer. They'd rather have false positives than false negatives. The warning is also clear that there is not a definitive causal link. If you want to trust individual anecdot
312.
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cthalupa
11mo ago
That is an out of range value for the two largest testing labs in the USA - Quest and Labcorp. Their upper end is 100. https://testdirectory.questdiagnostics.com/test/test-detail/... https://www.labcorp
313.
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cthalupa
11mo ago
If you go and tell your doctor you're having trouble with a statin, they should have you try a new one, yeah. Some might need to get clued in on pitavastatin, as it only recently went generic and insurance companies really didn't
314.
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cthalupa
11mo ago
I would agree that this article overstates a lot of things. ApoB is still a reasonable thing to check though, at least once - Lp(a) is the primary cause of atherogenic particle counts being high when LDL-C isn't the culprit, and it
315.
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cthalupa
11mo ago
> Memory loss and confusion have been reported with statin use. People reporting things doesn't mean much, because as your own original link mentions, people tend to overreport stuff when they are going to the doctor already for oth
316.
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cthalupa
11mo ago
Arguing against nonsense like this gets so exhausting. Statins do not destroy your muscles. Newer statins make this already exceedingly rare side effect even rarer, but let's look at them as a general class: https://pubmed.n
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cthalupa
11mo ago
How do people become experts on doing dangerous procedures on infants if they're not allowed to do dangerous procedures on infants until they're experts? I agree with most of what the author wrote, even a decent amount in the para
318.
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cthalupa
11mo ago
I didn't stop changing doctors until I found one that would work with me. I didn't go to a fancy concierge doctor - I just shopped around. I didn't go through a string all at once, but when I needed to go to the doctor, if I
319.
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cthalupa
11mo ago
You really should push for an ApoB test in general - most people are bit by LDL-C and not other atherogenic particles like Lp(a), but it's still common enough to find out. The good news is Lp(a) is largely genetic so if you know you ha
320.
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cthalupa
11mo ago
Every organ in your body that utilizes LDL can synthesize it de novo. Some of the heaviest users, like your brain, literally can't get it from your serum LDL levels - they do not pass the blood brain barrier. It is all synthesized loca
321.
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cthalupa
11mo ago
Even his LDL-C is bad. 116/119 are both out of range by most lab testing standards and the top end of range already allows for plaque deposition.
322.
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cthalupa
11mo ago
The National Lipid Association and American Heart Association have both been advocating that lower cholesterol numbers are better, e.g. https://www.lipidjournal.com/article/S1933-2874(25)00317-4/f... Research scie
323.
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cthalupa
11mo ago
Was it a CAC or CTA? It was almost certainly the former, and the former is is basically an indicator that the damage is already done. Soft plaque takes a long time to calcify. But soft plaque is the stuff that ruptures, and will clog up you
324.
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cthalupa
11mo ago
A single study showed a single statin reducing GLP-1 levels and ascribed it to gut microbiome changes that could be totally resolved with UDCA supplementation. If this even ends up being reproduced it at most says there is an easy fix for p
325.
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cthalupa
11mo ago
No, your post is nonsense. You link a random article that doesn't even make the argument that you're making - that it's low cholesterol causing the memory loss - or that statins are causing the memory loss at all. And conside
326.
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cthalupa
11mo ago
We have checked to see if they are addressing the problem more than probably any drug in history. The idea that we haven't is the result of skeptics cherry picking results that back up their point while ignoring the huge quantities of
327.
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cthalupa
11mo ago
https://www.lipidjournal.com/article/S1933-2874(25)00317-4/f... Guidance from the National Lipid Association, based on a review of the current understanding of the science across quite a few different meta-studies
328.
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cthalupa
11mo ago
> While statins have some significant side effects in many patients Some statins have significant side effect in some patients. We have many "new" statins that the overwhelming majority of people have no side effects on. Exceed
329.
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cthalupa
11mo ago
Diet and exercise are hugely important to health in general, and can make a significant impact on lipids. They are unlikely to get lipid levels down low enough to reach soft plaque regression levels. You need to get sustained levels below 5
330.
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cthalupa
1y ago
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