cryoshon

36 ms·

271.
by cryoshon 8y ago
yeah, i got this feeling too. the drug companies are desperate to make money off of alzheimer's, but the disease is too obstinate to go along with their wishes unless they juke the stats. improving cognitive function is very difficult
272.
by cryoshon 8y ago
originally i was going to write this entire trial off as a pharma industry snow job with heavily contrived data -- and it still might be -- but i think there's probably at least something worth talking about here. the drug slows progre
273.
by cryoshon 8y ago
kind of, but not exactly. benzos wipe out most of your ability to inhibit behavior along with your ability to form memories. it practically guarantees that you're a mess. your concentration goes to shit, along with most of your higher
274.
by cryoshon 8y ago
GWAS are great, don't get me wrong. but there's always a lot of jumping to conclusions that is done whenever a GWAS finds something interesting. afterwards, you find the people wishing that they could CRISPR themselves to fit the
275.
by cryoshon 8y ago
there's always more to find, but consider that this model is leaving out the environment entirely and its predictive value is even less than you might think at first glance. we know the environment impacts gene transcription, and we kn
276.
by cryoshon 8y ago
at the moment, there are telltale signs of deepfakes if you know what to look for. various video editing issues, image glitches (visible in the obama/ahmadinejad photo in the article), lighting inconsistencies, sound oddities, etc. fri
277.
by cryoshon 8y ago
taking all of the associations into account and making a polygenic predictor score "does a lousy job predicting the outcome for any specific individual, but it can explain 11 percent of the population-wide variation in years of schooli
278.
by cryoshon 8y ago
the joke is (probably) on you: most people know not to mention these things in a job interview, but expect to enter a team with like-minded individuals upon hiring. employers can't screen for it because there's no paper trail.
279.
by cryoshon 8y ago
>psychedelics can help people who had maladaptive experiences or upbringings make permanent improvements, that symptom relief drugs like antidepressants may even stand in the way of. this is my understanding as well. kind of like how a c
280.
by cryoshon 8y ago
yeah, one of the biggest misconceptions that i had was that it would be "fun" to try psychedelics. it wasn't fun, and it wasn't not-fun. it was different, and it was a learning experience. the long lasting effects were n
281.
by cryoshon 8y ago
step one is realizing that if you want to expand your mind you have to reject the systems of control that dictate to you which thoughts and behaviors are allowed. put differently: the barriers to experimentation with psychedelics are the on
282.
by cryoshon 8y ago
tell that to the royhinga who were betrayed by facebook and subsequently killed. i'll be waiting for the scientific advancements to be useful to the public. so far they've increased rates of depression, anxiety, etc while enabling
283.
by cryoshon 8y ago
you'd likely need this as well as the brain profile and several other profiles/fingerprints (liver history, etc) to really get to a complete model of drug action. so its a piece of the puzzle.
284.
by cryoshon 8y ago
which four? and how have you done it without money down?
285.
by cryoshon 8y ago
you've made an eminently prescient comment here. it explains why many scientists are self-denying and perfectionistic: failure is the rule during experimentation, and progress is not guaranteed or even knowable sometimes. i think that
286.
by cryoshon 8y ago
>just expensive prepayment. you have discovered their business model.
287.
by cryoshon 8y ago
this isn't a toe-in-the door surveillance maneuver to test the waters for people accepting it. this is scraping the barrel to get whatever last dregs of control remain. we can choose not to roll out the guillotines this time. but then
288.
by cryoshon 8y ago
false. even in extremely well-funded academic labs, journal access can be sparse. i have heard the line "i could only read the abstract for free, but..." from PIs more than a handful of times.
289.
by cryoshon 8y ago
agreed entirely. labor costs are nearly always discounted in the life sciences from my experience. there's two origins of this phenomena. the first is that people are accustomed to having graduate students, or worse, being graduate stu
290.
by cryoshon 8y ago
i'm glad there was an article written about this sociological phenomenon in the sciences. begging, sharing, bidding, _stealing_, fixing, and making do were the standard in every "poorly funded" (read: extremely well funded in
291.
by cryoshon 8y ago
>Its like cities in Cali forcing citizens to make drastic changes to conserve water, when over 90% is used by farmers yes, this is a common process by which private costs are offloaded onto the public so as to increase the private benefi
292.
by cryoshon 8y ago
enlightening is the right word. it isn't that his characters are interesting. they're multi dimensional but still mostly without an engaging personality (with the exception of the doctor from inversions and cheradenine zakalwe fro
293.
by cryoshon 8y ago
i only read consider phlebas after reading player of games as my introduction to banks. gotta say, consider phlebas didn't come off well at all. fairly flat, not really many interesting ideas or characters. kind of a generic space oper
294.
by cryoshon 8y ago
i've used the rule of 40 for quite some time now for both fiction and nonfiction. it does allow for some edge cases where you figure out that the remaining pages of the book will be very similar and mostly mediocre and you end up finis
295.
by cryoshon 8y ago
i've also used DDG for the last few years. it has indeed improved a lot. i don't really ever need to turn to google to get what i'm looking for these days.
296.
by cryoshon 8y ago
yikes, i really hope they are not so shortsighted these days. a lot of the time people are searching for something, they do not know exactly what they are looking for enough to articulate the perfect string of search terms and need a plate
297.
by cryoshon 8y ago
given the scale of our fiber networks, i'd expect coincidences like this. the more cynical side of me says that an intentionally crashed truck looks the same to outsiders as one that was crashed to cut the fiber line. but i really don&
298.
by cryoshon 8y ago
how can you play world of warcraft when your duty as a citizen remains unfulfilled?
299.
by cryoshon 8y ago
yes, but facebook "cares about user's privacy" and people here on HN will stick their head firmly into the sand and swear up and down that this is somehow excusable. violating privacy is their business model. there are no (ze
300.
by cryoshon 8y ago
a few interesting points here, but the author misunderstands one critical idea: science is always wrong by design. this is why the author claims that popper is irrelevant. he doesn't understand what popper understood: each scientific e

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