cknoxrun

11 ms·

61.
by cknoxrun 7y ago
I struggle with this one. We have been on the Google roller coaster a few times now, where for no apparent reason our traffic goes up or down wildly. From this I have developed a (likely) irrational fear that messing with things by removing
62.
by cknoxrun 7y ago
Good question. They had built a lot of internal tools and datasets that we rebuilt and released. It was a competitive advantage before.
63.
by cknoxrun 7y ago
Much of the information about existing drugs was organized, but within textbooks (Merck manual, etc). It had never been systematically structured and organized online (but likely internally within pharma). The data was (is) manually curated
64.
by cknoxrun 7y ago
My project in University (and now my company) annoyed a lot of companies when we first published DrugBank in 2006. We basically opened up the data on potential APIs and their targets into a downloadable and useable data set. I remember goin
65.
by cknoxrun 7y ago
Indeed, I was at a biotech drug conference in Berlin last year and was astonished at how little direct research large pharma are engaged in. They've completely offloaded primary research to drug development companies. Maybe it has alwa
66.
by cknoxrun 7y ago
A&W in Canada has a Beyond meat burger and a Beyond meat breakfast sausage sandwich. I go there semi-regularly (being the best fast food restaurant in Canada in my opinion) and I am astonished - almost every second person in line is ord
67.
by cknoxrun 8y ago
I just wanted to check in -- I've been using this for a few days now and love it. I would pay for this.
68.
by cknoxrun 8y ago
Unfortunately UMLS and Wikipedia are not good enough for drug information. Structuring that data requires a fine balance of tooling (with some NLP) and a good team of biocurators (doctors, pharmacists, pharmacologists and domain experts).
69.
by cknoxrun 8y ago
Keep in mind there is also the try! method to raise an error if the method does not exist (which is now likely implemented as &.)
70.
by cknoxrun 8y ago
An aside but surely this must be positive in terms of environmental impact. Imagine the millions (billions?) of desktops and laptops that have not been manufactured or powered because of the widespread availability of phones.
71.
by cknoxrun 8y ago
I love these burgers! They have actually helped me transition to completely beef-free since they address that occasional fast food burger craving. It’s interesting to note that A&W Canada is entirely separate from A&W in the US. A&a
72.
by cknoxrun 8y ago
I agree completely. For me part of the issue is that getting angry (or pretending to) does work at certain ages! Right now my 6 and 3 year old sleep in a bunk bed. The 3 year old lately has been prodding the 6 year old when they are suppose
73.
by cknoxrun 8y ago
Those three choices are interesting because I would absolutely take the designs of those sites from 10 years ago over the current ones.
74.
by cknoxrun 8y ago
I live and co-founded my current company in a colder northern Canadian city. Often we get derided by larger urban centres in Canada, similar to being labeled "flyover" country. But what I've found is that there is a sweet spo
75.
by cknoxrun 8y ago
Out of curiosity where are you located? I chatted with my partner, a K-6 teacher and here they get 30 minutes to eat followed by 30 minutes to play or go to an activity (like choir). This seems reasonable to me.
76.
by cknoxrun 8y ago
I would imagine several of the recipes are directed at families with young children?
77.
by cknoxrun 8y ago
It’s important to note that this is taught in schools starting from as early as grade 1. I do believe that teaching children about the joys of eating food and sharing meals could have a positive impact. Consider France, arguably one of the
78.
by cknoxrun 8y ago
You should give crystal a go for the parts you need to be performant! You can even prototype those parts in ruby and easily convert to crystal when it becomes necessary. We’ve found a really nice balance, with business logic and interfaces
79.
by cknoxrun 8y ago
I actually really enjoy using Safari, and I am not alone. The dev tools are great and the main extensions I use are available. Perhaps you can elaborate a bit more on your experiences with Safari?
80.
by cknoxrun 8y ago
Did you have your child in the US? If so I am curious, do the nurses come and visit your home the next day and a week after? I live in Canada and was very surprised when they came to check on the baby and my wife the next day, looking for j
81.
by cknoxrun 8y ago
This makes me think about data backups. It might make sense to only get a notification if a backup failed, but then how do you know the backup system is actually functioning at all?
82.
by cknoxrun 8y ago
Personally I’ve experienced something like this while reading fiction. The characters are so life-like and endearing in some books that I miss them and feel a loneliness temporarily after finishing. So I guess it isn’t just modern media, hu
83.
by cknoxrun 8y ago
I would highly suggest checking out Halt and Catch Fire. It's a period piece, but I think it captures the spirit of Northern California. The first 2 seasons are in Texas before they jump ship to San Francisco.
84.
by cknoxrun 8y ago
Fair enough, that does make sense. It's hard to understand how much the game has changed until you watch an older game from the 80's, it's a different flow entirely. On an unrelated note, I am lucky to have some very cherishe
85.
by cknoxrun 8y ago
Watching McDavid or Crosby on the ice, live, makes it very clear that they are still absolutely in a class of their own. I think these types of players are so good that they change quicker than the game can adapt. Crosby had some trouble in
86.
by cknoxrun 8y ago
Interesting coincidence, I just had lunch in the booth next to Wayne. He's a kind person.
87.
by cknoxrun 8y ago
Just to tack on to this, this is the cause of almost all drug-drug interactions and many adverse drug reactions. CYP450 is an incredible family of enzymes.
88.
by cknoxrun 8y ago
I wonder if it is also possible they associate you with searches your friends have done after being in the same location? So if you chat about going to Bali with your friends or co-workers, and one of them searches for Bali flights, they th
89.
by cknoxrun 8y ago
Basecamp purposefully remains small, so I am not sure if it is a recruitment tool, but it's possible. Basecamp has offered such a refreshing counterweight to the Silicon Valley unicorn mantra. I believe if some companies, such as Evern
90.
by cknoxrun 8y ago
Some of these look so similar to the ones I used to design. We used to call a single "swoop" where it would go down and glide back up a "neener-neener". The peak of our design was the "neener-neener 9", which I

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