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brandonb
searching PlanetScale…
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17 ms
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Apple Watch uses deep learning to estimate VO2Max
(empirical.health)
2 points
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brandonb
1y ago
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0 comments
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brandonb
1y ago
Andrew Ng has a nice quote: “Instead of doing AI, we ended up spending our lives doing curve fitting.” Ten years ago you'd be ashamed to call anything "AI," and say machine learning if you wanted to be taken seriously, but ne
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Kohler launches health tracker for your toilet
(kohlerhealth.com)
4 points
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brandonb
1y ago
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1 comments
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Counsel Health Grabs $25M for AI-Augmented Healthcare Service
(wsj.com)
1 points
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brandonb
1y ago
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brandonb
1y ago
Both this and Jesse's articles are great. Thanks for posting!
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The Scaling Era: An Oral History of AI, 2019–2025
(press.stripe.com)
3 points
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brandonb
1y ago
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Google working on high blood pressure screening with Pixel Watch
(9to5google.com)
2 points
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brandonb
1y ago
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Amgen says its cholesterol shot prevented heart problems in a broad population
(statnews.com)
3 points
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brandonb
1y ago
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Patients Are Diagnosing Themselves with Home Tests, Devices and Chatbots
(wsj.com)
6 points
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brandonb
1y ago
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brandonb
1y ago
Can you explain how? If I'm understanding the paper right, the timeseries encoding is a Conv1D and the cross-attention layer is constrained to output the token space of a pre-trained LLM. My naive expectation is these constraints would
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brandonb
1y ago
This is very cool! From the paper, this technique seems to work well for question answering in time-series. In medical AI, IMO, the most exciting work is detecting disease signals too subtle for humans—for example, estimating ejection fract
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brandonb
1y ago
Glad you're still with us! (And that you're seeing a cardiologist soon.)
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brandonb
1y ago
The closest thing I've seen is the antioxidant index from Samsung's latest Galaxy Watch: https://www.mobihealthnews.com/news/samsung-debuts-galaxy-wa... It specifically measures carotenoids through the optica
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brandonb
1y ago
FWIW, the linked article shows a specific biomarker that would change both medication and lifestyle, i.e., something you’d act on. The panel from the company above (I’m a co-founder) includes a review with an MD (not just an algorithm).
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brandonb
1y ago
The most recent evidence is that if you’re measuring ApoB and Lp(a), you’re capturing the same information as fractionation (with the bonus that the former two are slightly faster and cheaper at most commercial labs): https://aca
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brandonb
1y ago
My favorite definition of heart disease is "when circulating fats in the blood (lipids) are pushed by a driving force (blood pressure) into a vessel wall that is vulnerable (endothelial dysfunction)." IMO this gives a good mental
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brandonb
1y ago
Hi! Happy to help -- can you send me your debugging code (under Settings) if you haven't already? I'm bmb@empirical.health.
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brandonb
1y ago
Their comprehensive men’s panel is $200, which seems like the most comparable package. (The list of biomarkers above is a subset of the ones in our panel—obviously if you remove biomarkers, you’ll end up with a cheaper price.)
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brandonb
1y ago
I updated the above post to say (OP here). I thought it was fairly clear from my phrasing of "we offer the tests as cash pay", but never hurts to be even more explicit. I checked privatemdlabs.com, and they're asking $249 for
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brandonb
1y ago
Fair point!
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brandonb
1y ago
(OP here) LDL is still a good biomarker, but ApoB is a better biomarker for the same undelrying risk factor -- each atherogenic particle (LDL, VLDL, IDL) has exactly one ApoB molecule. The reason we offer the tests as cash pay is that it&#x
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brandonb
1y ago
Do you have a link to an article that covers the history? In the time that I've been following this topic (about 10 years), hs-CRP has been the go-to biomarker of inflammation. It'd be interesting to learn about the process requir
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brandonb
1y ago
The post links to the JACC article (which is an American College of Cardiology consensus statement).
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brandonb
1y ago
Note that the $190 panel includes not just hs-CRP ($59), but also the other major heart health biomarkers: ApoB ($69), Lp(a) ($49), A1c ($39), lipid panel ($59), eGFR ($99), other biomarkers, and a video consultation with a doctor to actual
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brandonb
1y ago
I certainly get the skepticism. You might find the JACC article (which is an American College of Cardiology consensus statement) interesting, since the ACC is a neutral party here (and reviewed all the evidence around hs-CRP).
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brandonb
1y ago
Chronic inflammation (a general systemic thing) is the thing we're mostly concerned about for heart health. The hs-CRP metric itself will pick up both acute inflammation (if you get sick) and chronic inflammation.
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brandonb
1y ago
Have you measured your Lp(a)? It's the strongest hereditary risk factor for heart disease. (Each Lp(a) particle is essentially a "normal" cholesterol particle with an extra protein that makes it 6x more atherogenic.)
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brandonb
1y ago
Recommended in addition to cholesterol (or better yet, ApoB). And recommended for everyone, not just those taking statins.
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brandonb
1y ago
It's more the former -- we've gotten so good at detecting high cholesterol and reducing it, that the majority of residual risk is now in the other factors. (There are some people who dispute whether cholesterol is causative, but m
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brandonb
1y ago
Interesting! That makes a lot of sense to me -- and I could see how Korey could get better over time at interacting with other agents (e.g., with Devin to actually fix a bug).
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