bhickey

33 ms·

331.
by bhickey 5y ago
> If the Spanish hadn't ever set foot on shore and the Mesoamerican society was allowed to develop, they would likely have developed their own diseases and the subsequent immune response, which may have helped fight Smallpox. The mo
332.
by bhickey 5y ago
> no mutable reference parameters Not anymore.
333.
by bhickey 5y ago
Your beliefs about the value of pog stocks has little bearing on the value of pog stocks.
334.
by bhickey 5y ago
I imagine they might haul Zuckerberg before the committee and spend a few hours asking him variations on "Why are you retaliating against Haugen?"
335.
by bhickey 5y ago
No. They're just another crypto pog designed to fleece dumb money with the hope that no one goes to jail for securities fraud.
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by bhickey 5y ago
From the article: because children are unvaccinated.
337.
by bhickey 5y ago
There's a huge gulf between getting sick attempting to make a virus more virulent and getting sick while gathering natural samples in the field.
338.
by bhickey 5y ago
> The fact that the entire clade has a root in October 2019... indicates that there was not slow community spread before the initiation of the pandemic period. There is no weaker progenitor virus. SARS-CoV-2 has an error checking polymer
339.
by bhickey 5y ago
HIV is believed to have first infected humans in the 1920s where it traveled up the Congo before arriving in Kinshasa. From there it radiated across Africa carried by truckers. Like you say, I haven't seen evidence to rule out rural ci
340.
by bhickey 5y ago
> as once someone is making a profit it can't be a positive-expected-value deal. This isn't true. There are risks an entity with a billion dollars can profitably take on that a person with a thousand dollars can't. Insuran
341.
by bhickey 5y ago
Yes, thank you. We need to look at the overall risk. To pick an extreme case: The unvaccinated IFR of rabies is close to one, but there hasn't been a rabies fatality in the US since 2018.
342.
by bhickey 5y ago
The data has never supported that covid is less dangerous than flu in kids. In the first year about 300 children in the US died from covid. Social distancing collapsed flu cases nationwide. There was a single childhood flu death last season
343.
by bhickey 5y ago
It's strange that they're narrowly focused on myocarditis. In the large scale Israeli vaccine safety study, researchers found elevated rates of kidney injury among covid survivors. Among confirmed pediatric cases the current hospi
344.
by bhickey 5y ago
The spike protein is under selective pressure. It needs to bind to ACE2 in order to reproduce. This constrains its mutational landscape. The viral envelope, for example, isn't similarly constrained and can undergo neutral drift. It wou
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by bhickey 5y ago
This is not a credible concern. Vaccination reduces the infection rate. Among vaccinated individuals who suffer breakthrough infection the time at peak viral load is significantly reduced.
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by bhickey 5y ago
> Is it to the price level (e.g. under $1K) where an individual patient could pay a lab to sequence their own virus sample? Sure. It'll run under $50 in bulk. Less, but not that much less, if you're only interested in sequencin
347.
by bhickey 5y ago
Rather than increasing efficiency, I'd be concerned about loss of function in the error checker. This would spike the mutational rate (and the mutational load).
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by bhickey 5y ago
I'll echo that this is a reasonable assessment. In evolutionary hill climbing, the fitter a protein the fewer paths there are to climb higher [0]. Art Poon has some interesting work that effectively maps viral phenotype space by lookin
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by bhickey 5y ago
Anyone want to ping Jason Scott on Twitter?
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by bhickey 5y ago
https://magazine.atavist.com/a-thousand-pounds-of-dynamite/
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by bhickey 5y ago
I've found myself using my second monitor as a fill light during video calls, so I put together a little site to make tuning the color simpler.
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Show HN: Keylight(keylight.us)
2 points by bhickey 5y ago|1 comments
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Operation Tracer(en.wikipedia.org)
1 points by bhickey 5y ago|0 comments
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by bhickey 5y ago
> anywhere in the world with a functioning local government will be similar. Boston does not have a functioning local government. A developer in my old neighborhood blocked a sidewalk for three years without a permit. Public works issued
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by bhickey 5y ago
> Did they know he had the operation? Yes and besides the big line of sutures down his sternum should've been a giveaway.
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by bhickey 5y ago
A few years back my father had a valve replacement due to childhood rheumatic fever. At ten days post op he woke up with an unstable heart rhythm and went to the hospital. They gave him drugs to get the rhythm under control, which failed. A
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by bhickey 5y ago
> In the top 10 contributors listed on GitHub, only 3 are not academic descendants of Felleisen: Eric Dobson and I were undergrads studying under Shriram. I don't contribute to Racket, but it has nothing to do with Felleisen being a
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by bhickey 5y ago
Run pooled testing on blood donations, sewage or airplane waste water.
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by bhickey 5y ago
https://www.economist.com/finance-and-economics/2018/03/15/w...
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Pineapple Pit(en.wikipedia.org)
3 points by bhickey 5y ago|0 comments

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