apathy

50 ms·

361.
by apathy 10y ago
Oh, also, for students: https://sigopt.com/edu I'm worried this is going to be like good Scotch for me.
362.
by apathy 10y ago
I could give a shit about the hyperparameter tuning (CV... it Works For Me) but your writeup of Gaussian processes and why they are called kriging in spatial stats is awesome. http://blog.sigopt.com/post/130275376068&#x
363.
by apathy 10y ago
Mm, probably best if the next time I have that sort of urge, I try writing it up and see if what I'm suggesting is even compatible with what the author sought to accomplish. I momentarily forgot how difficult it can be to stay tightly
364.
by apathy 10y ago
Fair enough! If you felt like adding it as a footnote, great, if it doesn't fit the purpose, that's fine too. And to reiterate, it's a beautifully laid out, concise, high-content piece of writing. I should have phrased it d
365.
by apathy 10y ago
Personally, I felt that the omission was rather important. When the first year's worth of many statistics programs can be condensed into one beautiful theorem, which is centuries old, I feel it's disrespectful to one's forebe
366.
by apathy 10y ago
Statisticians who hate probabilistic models might want to find another line of work. Like, say, philosophy. You use the phrase "involving Gaussians and stuff" to "clarify," and you ask others for rigor? Physician, heal
367.
by apathy 10y ago
Because, to quote Box, ‘To make the preliminary test on variances is rather like putting to sea in a rowing boat to find out whether conditions are sufficiently calm for an ocean liner to leave port!’ (Box 1953) Plot the residuals instead.
368.
by apathy 10y ago
Eh, orthogonalizing variables is a necessary precondition for this. When was the last time variables were totally uncorrelated and you didn't know it beforehand? Unfortunately such cases are the exception rather than the rule, and yo
369.
by apathy 10y ago
Ctrl-F "Gauss" 0 matches Ctrl-F "Markov" 0 matches The fuck? Only the single most beautiful result in the field. Please don't misunderstand me, the presentation is great and it is quite practical, I just wish
370.
by apathy 10y ago
COI: author is a "data science" recruiter and the field has not coalesced down to a static definition. Caveat lector
371.
by apathy 10y ago
nah its biggest strength is to use as IMC for tissue sections ;-) but yes, reading more carefully, I suppose you're right. Then again, orthogonal validation is not a bad thing.
372.
by apathy 10y ago
Well, that depends on the dose, doesn't it?
373.
by apathy 10y ago
Oh, you might be surprised
374.
by apathy 10y ago
thanks! It seems obvious now that you point it out, but that's how most good ideas work :-)
375.
by apathy 10y ago
right, but there's a reason we run clinical trials before accepting that something is superior to standard of care. It is really, really hard to manipulate a preregistered clinical trial (not that people don't try) and incredibly
376.
by apathy 10y ago
Doctors have to evaluate what patients say, too, and they're forgetful or clueless at least as often as anyone else. If the cost-benefit analysis favors having Watson (or whatever) around, great, if not, great, just another decision t
377.
by apathy 10y ago
Interesting! Great find on the selective inference, I should have known to look. Tucking this away for when it is needed.
378.
by apathy 10y ago
Most of the libraries for analyzing CyTOF data are already open (from Fluidigm). Did you already check for their data on Cytobank? Granted Nat Med is not as demanding re: reproducibility as say eLife or Bioinformatics, but they're not
379.
by apathy 10y ago
ps. Mouse data doesn't need to be anonymized :-)
380.
by apathy 10y ago
The code for Citrus is on GitHub (see online methods). The data was deposited into Cytobank, so if it isn't already available, you could ask them to release it (Cytobank is sort of like GEO for flow/CyTOF data). It's pretty
381.
by apathy 10y ago
Very odd. To my knowledge, STAG2 deletions or mutations don't respond any differently to most other primary or secondary AMLs. (In fact, usually a secondary AML is a worse diagnosis as it means they have progressed from something lik
382.
by apathy 10y ago
Well, to play devil's advocate, if all the tickets are free, and the attending gets to ignore all the ones that don't win, that could be useful. FWIW, here's Lukas' writeup of his experience. http://www.ncbi.n
383.
by apathy 10y ago
R is a glue language. The fast bits are always written in C++, FORTRAN, or wrapping a BLAS like LAPACK. R-vs-Python is almost never the problem in production. Interpreted-vs-compiled is almost always the issue. (I'm aware of Numba a
384.
by apathy 10y ago
not the OP, but glmnet is still the standard for lasso'ing, and I'm not aware of a Python implementation for post-selection inference and statistical testing yet. That said, the secret sauce in all of those is FORTRAN.
385.
by apathy 10y ago
I can't get past the adblocker spam, but I'm going to guess this woman had APL (acute promyelocytic leukemia, caused almost exclusively by a very specific chromosomal translocation) and the doctors didn't think to look for Au
386.
by apathy 10y ago
The actual paper is at http://www.nature.com/nm/journal/v22/n8/full/nm.4133.html I was going to see if it could be torn apart but 1) Shen-Orr is a very thorough, un-full-of-shit researcher, 2) I lik
387.
by apathy 10y ago
I was surprised when I read this, but only because the sheriff wasn't Joe Arpaio. Certain law enforcement officers apparently receive training in How to Ignore the Constitution and Laws of the State and Country That You Swore to Uphold
388.
by apathy 10y ago
A direct link to the PDF for ISL is here: https://web.stanford.edu/~hastie/local.ftp/Springer/ISLR_pri... The grownup version of that, ESL, is also available free: https://web.stanford.edu/~ha
389.
by apathy 10y ago
Hmm. I was hoping for things a little more advanced than "how to use EXPLAIN and CREATE VIEW". The various embeddable languages for Postgres (e.g. PL/R, PL/Python, etc.) would be a good topic for more discussion, IMHO.
390.
by apathy 10y ago
This advice applies to a lot more than just startups. Any time you're asking someone for (real) money -- grants, etc -- the evaluation will be like this: 1) What are you proposing to do? (proposal) 2) Will it make any difference? (

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