amts

9 ms·

31.
Ask HN: What ML/AI architechtures used in chemistry/biology, engineering?
3 points by amts 3y ago|0 comments
32.
by amts 3y ago
Strangely enough he is taking NR (nicotineamid riboside) rather than NMN, probably as there was recent evidence (including on HN) that NMN can evoke cancer (in those who are prone to cancer or already have it).
33.
by amts 3y ago
>> There are some formulations that purport to have higher bioavailability on a gram-for-gram basis according to trials, but their price is often high enough that it’s cheaper to take more of a generic CoQ10 than to buy an expensive f
34.
by amts 3y ago
>> This in turn has been linked to under-methylation, and mitochondria play a role in a lot of processes involving methylation. Do you mean epigenetic methylation? As the cellular reprogramming techniques for example strive to reverse
35.
by amts 3y ago
The neuroscience-based literal cures for bullshit are the following: 1) temporal reduction of serotoninergic transmission in the right hemisphere of the human brain; 2) caloric vestibular stimulation (of the left ear); all of which are supp
36.
Ask HN: Should I learn more of Excel/Power BI if I'm cracking on Python?
4 points by amts 3y ago|5 comments
37.
by amts 3y ago
It's basically as Python keyword 'as' implies: spacetime and whatever it contains including gravitational bending being a data structure (one of many), which obviously is not just another object in spacetime, but spacetime it
38.
by amts 3y ago
Spacetime as a data structure
39.
A powerful heat transfer infrastructure with capability of power generation(sciencedirect.com)
1 points by amts 3y ago|0 comments
40.
Andrew Steele: Curing aging is a question of investment, not time(longevity.technology)
3 points by amts 3y ago|0 comments
41.
by amts 3y ago
Ion channels are also a hyper-conserved mechanism as every cell needs to maintain a resting potential, and there are tons of ion channel modulating drugs approved and used messing with the with billion years old hyper-conserved mechanism. I
42.
by amts 3y ago
I heard about this anti-oxidant hype, so the original psilocybin study now seems a bit incomplete. There are a ~dozen of studies on dasatinib (anti-cancer drug) + quercetin (senolytic) for curing osteoarthritis in humans, improving heart ti
43.
by amts 3y ago
I'm not trolling, this probably is some effect of the psychoactives' field itself and thinking about it. I am researching the topic about how signalling molecules find their intra- and extracellular targets amongst multiple potent
44.
by amts 3y ago
Do you mean that it is the OH group on psilocin that binds with the receptor? There probably are many other compounds with an OH group and another backbone, and they are not supposed to bind with 5HT2a. The OH group is ~0.62% of the whole
45.
by amts 3y ago
Yep, get yourself a bs job first while implicitly getting yourself stroke, cancer and diabetes from it to pay for utilities and a few gallons of water per month and only then do great work.
46.
by amts 3y ago
Seems like psilocin is dephosphorylated psilocybin. But the main working indole structure with the side chain is preserved. So for a cell to get an extra phosphate rich in energy while producing psilocin for the host should be a bonus. The
47.
by amts 3y ago
Yep, they show it's not a senolytic, but I'd like to see an experimental human group (preferably with a dopamine transporter allele making them more prone to placebo-like responses) being given psilocybin and told that it is a sen
48.
by amts 3y ago
>>Surely there are downsides (cancer, ...) Me doesn't quite understand the rationale behind this widely used argument. Ok, senescent cells emerge as a mechanism to ward off cancer. They are basically semi-cancerous cells with an
49.
by amts 3y ago
State of senescence in cells can also be caused by mechanical stress [1], this is the basis of senescent cell formation in osteoarthritis etc. So maybe psilocybin is somehow generalizing. [1]. https://www.ihmc.us/stemtalk&#x
50.
by amts 3y ago
>>Evolution doesn't seem to optimize for longer lifespans. Not quite true (if not weighting high on optimization). There are multiple species which are outliers by lifespan in their niches: whales, hydras, etc. Even within rodent
51.
Psilocybin Decelerates Cellular Senescence(assets.researchsquare.com)
31 points by amts 3y ago|21 comments
52.
Turn Biotechnologies Founder to Be Featured at Japanese Society of Anti-Aging(prnewswire.com)
2 points by amts 3y ago|0 comments
53.
by amts 3y ago
~"Part of an answer to a question lies in the definition of the question" (c) some famous physicist. James Fadiman also conducted research on microdosing aiding problem solutions.
54.
by amts 3y ago
There is nothing related to "insulting or condescending". >>You seem to Is backed by experimental neuroscience research (not as much by "logical arguments") and it is obviously not = to "you are". The fac
55.
by amts 3y ago
Does Altos Labs applies anything like that? Seems like not a lot. And yet morphoceuticals.com achieves ~5x more in mice than Sinclair's epigenetic reprogramming with OSK genes, as apart from just the tissue of an optic nerve they regen
56.
DeforMoBot: A Bio-Inspired Deformable Mobile Bot for Navigation Among Obstacles(ieeexplore.ieee.org)
1 points by amts 3y ago|0 comments
57.
by amts 3y ago
The anti-aging effects of rapamycin support the opposite of "pervasive accumulation of entropy" theory - which is that aging is a distorted development program, rather than random accumulation of entropy. The definition of "r
58.
Ask HN: Which progcourse would you recommend for paid certificate of completion?
1 points by amts 3y ago|0 comments
59.
Ask HN: Is C# worth learning to only get a formal job?
2 points by amts 3y ago|2 comments
60.
Ask HN: Is certificate of completion better or a portfolio of projects?
4 points by amts 3y ago|4 comments

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