amluto

13 ms·

301.
by amluto 4mo ago
LNPs have limited capacity, and if the CRISPR/Cas system they’re using requires an exact match, then any additional point mutation or insertion or deletion in the segment being matched would allow the cell to survive. I suppose that a
302.
by amluto 4mo ago
Old computers, before double-buffering and compositing, were fast . Single-digit millisecond latency from input to output was common. Now it’s 30-ish years later and computers have not recovered the latency increase from compositing, doub
303.
by amluto 4mo ago
> rendering direction should follow reading convention. What does that even mean in this context? In a strictly LTR language, sure, you read left-to-right and the glyphs are rendered left-to-right. But the whole discussion is about bidi
304.
by amluto 4mo ago
It does seem like a KP-like algorithm ought to be able to optimize the break positions without extreme algorithmic difficulty aside from the inputs being considerably more complex than for Latin block print: the cost function for a proposed
305.
by amluto 4mo ago
Is this a small typo? > The relevant rule, W2 of UAX #9, reclassifies a digit as an ARABIC NUMBER if any of the previous strong characters in the paragraph were Arabic letters, and as a EUROPEAN NUMBER otherwise. Both render their intern
306.
by amluto 4mo ago
It’s not so brilliant when you have an array of size 2^n and you append and then pop off the end in a loop and each operation takes time proportional to the length of the vector. Usually, dynamic arrays aim for amortized constant time for a
307.
by amluto 4mo ago
Surely a far simpler way to evolve resistance would be a trivial mutation in the p53 transcript that the guide RNA is looking for.
308.
by amluto 4mo ago
I disagree. Regulations or not, building a terrestrial network is expensive. Once all the permits are granted, it still costs on the order of $5/foot ($25k/mile) to buy and install fiber. (Cost varies with labor costs and by insta
309.
by amluto 4mo ago
It's not quite in the same category, but there's also Zhuyin Fuhao: https://en.wikipedia.org/wiki/Bopomofo
310.
by amluto 4mo ago
> Why is this thing so slow? It took me five minutes to store a 400 line text file! > Well, this is just an initial prototype, and don't worry, there's always Moore's law! Seriously? They're only storing individua
311.
by amluto 4mo ago
Here's the thing. Land is cheap in many parts of the world. Solar panels work okay on the ground (not as well as in space). GPUs work better on the ground (MUCH easier to cool). Connectivity is cheaper on the ground (sure, Starlink
312.
by amluto 4mo ago
It’s worth noting that Anthropic has made some very odd moves in the last few months in which Claude Code reviews your usage of it and penalizes you for mentions of some short strings that don’t even indicate TOS violations. And if they’re
313.
by amluto 4mo ago
I am not an expert, but I do know some physics and I know how to read, and I’m pretty sure this is full of BS. Also it’s a really crappy visualization.
314.
by amluto 4mo ago
IANAL, but this seems wrong. In an alternate universe, Let’s Encrypt has a chat with someone and then states, publicly, like a speech, that they think that person owns a domain. In our universe, Let’s Encrypt lets a client open an “account”
315.
by amluto 4mo ago
I think the intent was to specifically train an LLM to judge what a specific maintainer would consider to be good style.
316.
by amluto 4mo ago
That blog post really makes it look like it's graded from an LLM's estimation of an OSS maintainer's review. I see three issues: 1. That estimate could easily be wrong. 2. That estimate is, of course, usable in RL training.
317.
by amluto 4mo ago
This isn’t that big a win. If you put the radiator in the shadow of the solar panels then a good fraction (which depends on the geometry) of the radiated heat from the side facing the panels hits the panels and warms the panels, and the rad
318.
by amluto 4mo ago
That cooling system is … aggressive. 110m^2 of radiator to dissipate 120kW average heat. That’s about 1.1kW/m^2, which works out to very close to 100C at the radiator under absolutely perfect conditions (absolute zero ambient temperat
319.
by amluto 4mo ago
I still don’t see it. The equipment is very, very expensive, is subject to shortages, and has residual value after five years. But these very low Earth orbit satellites literally burn up when they run out of fuel for station keeping. Even i
320.
by amluto 4mo ago
Help me out here, please. Off the top of my head, the exec command is dependent on exec, except that a spawn + wait implementation would be a mostly okay substitute. Pipes and redirections don’t need fork + exec. Neither do subshells.
321.
by amluto 4mo ago
SpaceX may well revolutionize multiple markets. But I really don’t see the sub-business of building large datacenters and leasing them out, hopefully at a profit, as revolutionizing anything. Also, SpaceX has no particular competitive advan
322.
by amluto 4mo ago
Linux has worked pretty hard to optimize fork(). This doesn’t mean that fork() is a good idea. Windows does not historically depend on fork(), so there was no native fork(), so Cygwin kludged it up.
323.
by amluto 4mo ago
I am comparing SpaceX’s datacenter-and-GPU leasing business to aircraft leasing. It’s possible, and common, for one large company to have multiple business lines, each worthy of a very different P/E multiplier. In principle you end up
324.
by amluto 4mo ago
A way to pass a defined list of handles to a subprocess (or a friendly other process) makes sense. Having that mechanism be direct inheritance of those handles with the same numbering as the source is obnoxious.
325.
by amluto 4mo ago
I sincerely hope the market is not willing to value this sort of deal at a P/E ratio anywhere near 94. Off the top of my head, there is a very well established business involving buying expensive things and leasing them to the companie
326.
by amluto 4mo ago
I have the entirely opposite opinion. IMO a big mistake of the UNIXy model is that so much state is preserved across the creation of a process. For example, there are APIs to have a specific thing be fd number 4 so you can run a program an
327.
by amluto 4mo ago
Ugh. The source comment, which this was literally a copy and paste of, had newlines. I wish HN could roundtrip from itself via the clipboard correctly.
328.
by amluto 4mo ago
Wow, it’s almost like you can use it as if you’re just calling the LLM directly. What a crazy innovation!
329.
by amluto 4mo ago
Reposting my previous comment because the post I commented on earlier was flagged to death: This is kind of a sad situation. Tridge is an excellect programmer and a very respected member of the community, and I totally get it. rsync, like m
330.
by amluto 4mo ago
> All modern Romance languages have universally merged or dropped various of these features. Wikipedia informs me that Romanian is a Romance language and has retained some of it. Also, the Slavic languages have largely retained most or a

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