adonovan

22 ms·

271.
by adonovan 7y ago
Why are gene therapies so expensive? Is it simply the need to recoup high R&D costs across a smaller "market" of patients with rare diseases? Or is the marginal per-patient cost actually higher than a regular pharmaceutical?
272.
by adonovan 8y ago
When I started working at Google 14 years ago its most striking feature was the contrast between its external secrecy and its internal transparency. Essentially all engineering information was accessible to all engineers. Obviously the comp
273.
by adonovan 8y ago
Some images here hint at the methodology: https://phys.org/news/2018-06-scientists-bees-concept.html The number of ink marks (a discrete quantity) was varied independent of the mass of ink; the bees aren't just gr
274.
by adonovan 8y ago
It's true. Some of the greatest minds have spent 20 fruitless years trying to discover a unified theory of object fields and elementary values in JavaScript.
275.
by adonovan 9y ago
After further digging I think you're probably right. Variants of this story seem to have been reported in many countries over many years but none cites an actual authority such as government report or scientific paper. Copper theft do
276.
by adonovan 9y ago
Those cans are filled with transformer oil, which until relatively recently consisted mostly of polychlorinated biphenyls or PCBs. Imagine how many of those cans exist across the United States and you get a sense of how big the PCB industr
277.
by adonovan 10y ago
Also, a []Fooer supports the operation of storing any element assignable to Fooer, whereas a slice []fooint does not support that operation, so it makes sense that a []fooint cannot be used anywhere a []Fooer can.
278.
by adonovan 10y ago
In Sleepwalkers (great book), Arthur Koestler argues that many senior church figures were keen and supportive followers of Galileo's physical investigations, but repeatedly warned him not to cross the line between observing the univers
279.
by adonovan 10y ago
Gravity and Levity presented in 2009 a much better intuitive model and mathematical principle that explains this bold pronouncement: https://gravityandlevity.wordpress.com/2009/07/08/your-body-...
280.
by adonovan 10y ago
"To achieve that kind of speed and resolution, the [Connectom] machine draws 22 megawatts of power" Can that be right? The average large US hospital uses only 2.1MWe on average. Source: Table H6 of https://www.eia.gov&
281.
by adonovan 11y ago
This kind of optimized placement could in principle be done by a sufficiently smart compiler, but no such compiler exists. That's why existing compilers allow their users to control layout by, as you say, relying on an implementation
282.
by adonovan 11y ago
The most compact representation is not always the most efficient. If two fields in the same struct variable are accessed by different goroutines, placing them far apart so that they reside in different cache lines may avoid a great deal of
283.
by adonovan 11y ago
(Former Blaze engineer and current Go tool builder here.) Blaze's support for building Go source code predates the existence of the 'go' tool and uses very different conventions for package naming, directory layout, testing,
284.
by adonovan 11y ago
It shows its age. The straight white man is literally at the center of the universe.
285.
by adonovan 11y ago
> But in the Midwest and Northeast, where the electricity grid tends to rely on coal power plants, the damage from emissions ranged back up toward five cents a mile. I'm very skeptical of this claim. NYC and Upstate NY are known to