abhishaike

6 ms·

31.
A 2026 look at three bio-ML opinions I had in 2024(owlposting.com)
28 points by abhishaike 9mo ago|3 comments
32.
The ML drug discovery startup trying hard to not cheat(owlposting.com)
1 points by abhishaike 9mo ago|0 comments
33.
by abhishaike 9mo ago
I don't disagree!
34.
The Origin of Rot(owlposting.com)
10 points by abhishaike 9mo ago|2 comments
35.
by abhishaike 10mo ago
Thanks for posting this here! Sent this HN link to the founders, so they may be able to answer any Q's that people have
36.
We don't know what most microbial genes do. Can genomic language models help?(owlposting.com)
6 points by abhishaike 10mo ago|0 comments
37.
Bringing organ-scale cryopreservation into existence(owlposting.com)
2 points by abhishaike 11mo ago|0 comments
38.
by abhishaike 1y ago
>molecules get screened against tox targets sure! i cover this in the essay, the purpose of this dataset is not just toxicity, but repurposing also >toxicity of major metabolites this is planned (and also explicitly mentioned in the a
39.
Mapping the off-target effects of every FDA-approved drug in existence(owlposting.com)
162 points by abhishaike 1y ago|37 comments
40.
Cancer has a surprising amount of detail(owlposting.com)
3 points by abhishaike 1y ago|0 comments
41.
by abhishaike 1y ago
<3 high praise, appreciate the kind words
42.
by abhishaike 1y ago
I completely agree, but I also think there is some truth to the related statement: 'cancer research often isn't conducted in a way that is actually useful'! For example, in-vivo tumor experiments in mice can yield completely
43.
by abhishaike 1y ago
thanks for posting this here!
44.
Ask not why would you work in biology, but rather: why wouldn't you?(owlposting.com)
3 points by abhishaike 1y ago|0 comments
45.
by abhishaike 1y ago
Fixed!
46.
by abhishaike 1y ago
I think it has very limited therapeutic applications with what we know about RNA structure today ! But there's a great deal of completely unknown RNA biology (some of which I touch on in the essay) that may greatly benefit from RNA st
47.
by abhishaike 1y ago
oh yeah, I didn’t mean to say that they did claim that, that was just my (mis)conception
48.
RNA structure prediction is hard. How much does that matter?(owlposting.com)
70 points by abhishaike 1y ago|10 comments
49.
How do you use a virtual cell to do something useful?(owlposting.com)
2 points by abhishaike 1y ago|0 comments
50.
Mapping the off-target effects of every FDA-approved drug in existence(owlposting.com)
2 points by abhishaike 1y ago|0 comments
51.
by abhishaike 1y ago
This is in the article!
52.
by abhishaike 1y ago
+1 to this! I've also written a potentially helpful coverage piece on extracting conformations from cryo-EM data: https://www.owlposting.com/p/a-primer-on-ml-in-cryo-electron...
53.
by abhishaike 1y ago
Author here, I wish I added a section on coarse graining as well :) hope you write a post about it!
54.
by abhishaike 1y ago
Writer of the article here: randomization fixes most of this, but the other commenters are correct in that doesnt fully account for the clinic performance (e.g. nurse performance, which does dip during the night according to the literature)
55.
Administering immunotherapy in the morning seems to matter. Why?(owlposting.com)
239 points by abhishaike 1y ago|194 comments
56.
Some of my favorite pessimistic scientific articles(owlposting.com)
1 points by abhishaike 1y ago|0 comments
57.
Drugs currently in clinical trials will likely not be impacted by AI(owlposting.com)
2 points by abhishaike 1y ago|0 comments
58.
Drugs currently in clinical trials will likely not be impacted by AI(owlposting.com)
3 points by abhishaike 1y ago|0 comments
59.
by abhishaike 1y ago
<3
60.
by abhishaike 1y ago
I mention this in the article :)

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