ShannonAlther

11 ms·

61.
by ShannonAlther 9y ago
The article says that the developers expect companies to add their own features and support, so I guess we're just waiting for some established player or startup to pick up the ISA and roll something out with it? But it specifically sa
62.
by ShannonAlther 9y ago
> Unless you are driving quite a long distance and/or on the open highway, car travel is not as much faster than foot travel as some people seem to believe. The average speed limit on municipal roads in Ontario is 50 km/h, whic
63.
by ShannonAlther 9y ago
This is only true for certain scales relating IQ to construction costs. The average IQ in Africa is, what, ~15 points lower than America? Suppose the first 2 points increase construction costs by a factor of 1.5, and each subsequent 2-point
64.
by ShannonAlther 9y ago
If you're a little faster than average on the draw and have money to burn, the profits from the successful investments outweigh the money lost on the unsuccessful ones. E.g. if you have $50k, and spend it on five companies, only one of
65.
by ShannonAlther 9y ago
I think he means that the USD is valid currency for all debts, public and private, and this law is enforced by the US gov't.
66.
by ShannonAlther 9y ago
I'm more interested in immunology than respirology so I know very little about CF. Your idea sounds plausible (I'd give credence to the possibility that reducing stress is part of it, and maybe also the placebo effect), so some da
67.
by ShannonAlther 9y ago
Then I will ask directly: what lifestlye interventions have you implemented, and how are they helping you? Edit: Nevermind, you said it involved dietary change to handle acidosis. That's great, but is it related to the bacterial proble
68.
by ShannonAlther 9y ago
I don't believe I've been disrespectful or dismissive at all. I included the reasons I think you're mistaken, and I've cited Wikipedia because going through the back issues of the NEJM and the Canadian Respiratory Journa
69.
by ShannonAlther 9y ago
Δ That's really insightful. Thanks for taking the time to talk to me!
70.
by ShannonAlther 9y ago
> Your claim amounts to refuting the idea that anything new can be done, that the outcomes we currently have is as good as it gets. Poppycock. The Wikipedia page lists a small handful of promising technologies[0], and there are others no
71.
by ShannonAlther 9y ago
I still don't believe it's possible, at least not often. Hiring a senior rockstar/ninja/10x whatever means you have to offer them more money than they're currently making (which you have to imagine is a lot) and&#x2
72.
by ShannonAlther 9y ago
I don't believe I've accused you of anything except being wrong, Mz, and furthermore your blog notes that you have a rare CFTR mutation, a milder form of the disease (I only briefly scanned so I may be wrong). That's awesome!
73.
by ShannonAlther 9y ago
I don't think that demographic exists (really motivated people with 20 years experience). I remember Paul Graham saying something along the lines that he would never do the startup thing again even if he was dead sure it was a good ide
74.
by ShannonAlther 9y ago
That's really interesting and makes sense. However, given how common credit is, the fact that you must accept USD as payment in the US means that USD circulation is going to be really high, and therefore vendors that don't accept
75.
by ShannonAlther 9y ago
Misleading title; Amazon is hiring experienced engineers for their experience. They can do this because they can afford it, and they are doing it because they want to enhance their services. None of this demolishes "the cult of youth
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by ShannonAlther 9y ago
There are many reasons why a single currency may be preferable to many in a single market. The biggest is company scrip[0] but there are others, like the fact that this just creates more market speculation and that vendors have the option
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by ShannonAlther 9y ago
Since you actually have CF, it would be trite to point out (but I will anyways for the peanut gallery) that the mutation in the CFTR gene causes secreted mucous to be much thicker than necessary. In the lungs, this causes difficulty breathi
78.
by ShannonAlther 9y ago
JD.com thinks this will be an efficient way of maintaining a transportation network in the future. I'm not convinced, mostly because it seems like the fuel cost would be much greater. Feel free to let me know if I'm wrong though.
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by ShannonAlther 9y ago
> "54,000 potential cases... and 33 of the cases reviewed involved children." That's 0.06% of reviewed cases, which is frankly less than I would have thought. I suspect that child abusers are a more savvy lot than the aver
80.
by ShannonAlther 9y ago
Children are expensive and time-consuming, because in our society we're expected to take care of them, and the standard for that is very high. In developing countries, the standard is much lower and children are able to help run the
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by ShannonAlther 9y ago
Bloomberg, apparently. It's just like day trading: sure, you might get lucky, but you have to know or have something the rest of us don't to get consistent returns. Just invest in an index fund.
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by ShannonAlther 9y ago
> (Also, falling out.) More or less the same way headphones do.
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by ShannonAlther 9y ago
I don't think Nintendo ever stopped creating content for their consoles.
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by ShannonAlther 9y ago
> I mean, he could have started with a low performance, average-looking, electric, family sedan. There are other reasons Tesla started with a high-end model. Because building the cars was going to take a lot of R&D, Tesla supported t
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by ShannonAlther 9y ago
> How, pray tell, does anything "perform risk reduction"? Does that phrase have any meaning in English, or any other terrestrial language? This may not be what you meant, but suppose that my sister Alice is an alcoholic, and dr
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by ShannonAlther 9y ago
Ah, makes sense. But ratings and likes serve another purpose: determining which content is worth looking at. Snapchat aside, those services have the following they do because the content is tailored to the user: Facebook has their algorithm
87.
by ShannonAlther 9y ago
I confess that I can't see what gradient this ranking follows. It looks like the users get progressively more anonymous, except Reddit has the most anonymous users and it's in the middle; it also looks like the average use time pe
88.
by ShannonAlther 9y ago
Well, grocery stores already do that. And it's hard to imagine what a 'healthier version' of an app, say Spotify, would look like. Unless you're suggesting they move to Netflix's business model, but that's a ma
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by ShannonAlther 9y ago
Maher concludes that this was successful due to 'asymmetry' between the devices that wrote the disk and the ones that read it had different capabilities, but the actual reason is probably due to the creativity and complexity of th
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by ShannonAlther 9y ago
Netflix's incentive structure is slightly different: they want their clients to enjoy the service , so that they will be inclined to subscribe to them in the future. Spotify, on the other hand, wants to maximize time spent using the

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