Real_S

10 ms·

61.
by Real_S 8y ago
This reminds me of the calorie restriction research done in fruit flies (e.g. [1]). They found that protein was toxic to fruit-flies, and then journalists foolishly extrapolated that to humans. Apparently, feeding fruit-flies yeast extra
62.
by Real_S 8y ago
Interesting... so it looks like RTX can cause cell death. Perhaps this shouldn't be surprising. Glad you updated that link.
63.
by Real_S 8y ago
The TRPV1 receptor is present on sensory nerves, so although it does primarily detect high temperature[1], regulating it can result in pain relief in general, not just a reduction in "burning sensations." Also, the article simpli
64.
by Real_S 8y ago
DNA is not fragile, and can act as a very stable long-term storage medium. DNA in living cells has some fragility because it is in an aqueous solution and also actively used to generate RNA. DNA out side of cells is even more fragile, it w
65.
by Real_S 8y ago
Also consider that cryptography can be applied directly to DNA molecules. Cryptography for genetic material: https://www.biorxiv.org/content/early/2017/06/30/157685
66.
by Real_S 8y ago
Also, consider that read-speed is rapidly improving. So for long-term storage, reading the data at a reasonable rate in the future is almost guaranteed. Hopefully write-speed will reach a similar rate of improvement. Importantly, expected
67.
by Real_S 8y ago
Interesting thoughts. Encrypting dna molecules is possible, but it probably wouldn't use a virus. Also, if your cell's DNA was changed like this, it would kill you very quickly, interfering with normal cellular function.
68.
by Real_S 8y ago
>New techniques ... may soon make the anonymity of their customers’ DNA impossible to safeguard I strongly disagree. >He suggested it might be wise to encrypt genetic data to protect personal information. Maybe we can encrypt DNA mole
69.
by Real_S 8y ago
I often find interesting research and/or tech advances outside of my immediate field of study. Also, articles on startups here may have influenced my journey as a founder ;)
70.
Future Founders, Here’s How to Spot and Build in Nonobvious Markets(firstround.com)
2 points by Real_S 8y ago|0 comments
71.
by Real_S 8y ago
And this affects life insurance, so you wont be alive when they dispute your claim!
72.
by Real_S 8y ago
Also, before you send your DNA off... Keep in mind that these companies are not legally allowed to delete your data. https://www.bloomberg.com/news/articles/2018-06-15/deleting-...
73.
by Real_S 9y ago
The intermixing was complex. Many groups migrating and interbreeding at various times. https://www.nytimes.com/2015/02/20/science/a-new-theory-on-h...
74.
by Real_S 9y ago
Unfortunately, there is limited interest in genome privacy. There is also a BIG interest in getting people to surrender their genomes. ""But its for the good of humanity, so don't worry about any possible downside."&quo
75.
by Real_S 9y ago
>if you want to get the kit and test your DNA out of fun, at least make sure your identity is not obvious. DNA can be used to identify the person it came from!!! If you send off your DNA with a different name, there are many ways that th
76.
by Real_S 9y ago
Short answer is yes, but it depends on the relationship and the disease. For example, if a parent takes the test and is positive for a breast cancer risk genetic variant, then all offspring will have at least a 50% chance of the same resu
77.
by Real_S 9y ago
Unfortunately, GWAS data is unlikely to unlock the secrets of human genetics. We have been in the "post-GWAS era" of genetics for at least a few years now. > And it's not that big a deal. We will be much better off for i
78.
by Real_S 9y ago
This is an incredibly important point! Openly sharing your genetic information makes both you AND your relatives more vulnerable, with vulnerability decreasing as relatedness decreases. It also reveals potentially sensitive information abo
79.
by Real_S 9y ago
These data can be used to identify their source. This will become easier as more data becomes available. https://news.ycombinator.com/item?id=15209306 I guess the value of the data depends on who measures its worth. Repli
80.
by Real_S 9y ago
This article fails to mention any privacy risks to the volunteers. GWAS have proven to be, at best, of little value. In fact, due to the unfortunate way that many researchers chase p-values, these analyses often result in misdirection. What
81.
by Real_S 9y ago
Yes, the assumptions they have made to draw their conclusions are highly suspect, especially considering that we have a limited understanding of the genetics of pigmentation. Looks like they are overstretching. My suspicion is that this i
82.
by Real_S 9y ago
There is more on this, to be released here with sufficient interest or to be shared with interested parties...
83.
Cryptography for genetic material (2017)(biorxiv.org)
5 points by Real_S 9y ago|1 comments
84.
by Real_S 9y ago
>It is amazing to think that even the rate of mutations is probably an evolutionary response to the environment. Now consider that mutation is not a single "rate" across the genome. Instead, mutations are targeted to specific
85.
by Real_S 9y ago
Interesting connection with brain complexity, but note that the function of the Huntinton's gene remains poorly understood. Something that may be related... The same unstable repeat that causes the disease is ancient and is conserved t
86.
by Real_S 9y ago
There is something important about the type of mutations that drive Huntington's. Huntington's is caused by an expanded repeat composed of (CAG)n with n>40 repeats. Due to the instability of repeat regions, new mutations arise
87.
by Real_S 9y ago
1. You are perceptive, this is usually something to watch out for. However, it does not always indicate that a study is flawed, just that the research might have met with unwanted resistance, and the authors are in position to avoid that r
88.
by Real_S 9y ago
Population structure is controlled through the use of the structure as a co-factor in the analyses. They use a principal component analysis on the genotypes to estimate the structure, and then use the first few principal components (PCs) a
89.
by Real_S 9y ago
Interesting conflict between these researchers. From Erlich [0]: "The take home message should be that identifying someone in a group of ten people requires very little effort. Anyone with access to even low dimensional data, such as b
90.
by Real_S 9y ago
After looking through the Contents of both: CASI looks very cutting edge, but also covers the origins of the use of computers for statistical methods. So this covers how computers can and have been used to do statistics. FoDS looks like a

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