Kalanos

11 ms·

121.
by Kalanos 2y ago
.py is undeniably more widely compatible in production envs than .ipynb
122.
by Kalanos 2y ago
why the downvote? debate me. it's saturday and i'm working in jupyterlab
123.
by Kalanos 2y ago
as a daily jupyter user, i like this .py DAG approach a lot - more so for visualizing complex workflows than addressing a potentially corrupt hidden state. there isn't much *data science functionality* integrated into jupyter core apar
124.
by Kalanos 2y ago
i spent time w pluto. it's not at parity
125.
by Kalanos 2y ago
if it installs
126.
by Kalanos 2y ago
i wish they actually got snaps working before forcing them
127.
by Kalanos 2y ago
rather than invoking the script with arguments, you could just define the variables at the top of the script and run it
128.
by Kalanos 2y ago
different cell types express different genes at different amounts at different times each tumor cell/ subclone has different mutations at different times
129.
by Kalanos 2y ago
Yes, it's a different term and entirely separate category of drugs. Checkpoint inhibitors cut the brakes. This reduces their ability to detect "self," and attack blindly. What they don't do is poke immune cells with a st
130.
by Kalanos 2y ago
For interactive charts, simple APIs, multi-language compatibility, and interactive apps (Dash) https://plotly.com/python/
131.
by Kalanos 3y ago
By the time data has been preprocessed for ML, it is numerically encoded as floats, so .npy/npz is a good fit and `np.memmap` is an incredible way to seek into ndim data.
132.
by Kalanos 3y ago
halo 3 online?
133.
by Kalanos 3y ago
Exactly. There are a hundred questions that come to mind like how does it handle concurrent writes, sharding, views. https://en.wikipedia.org/wiki/Database#Database_management_s... I'm sure they learned a lot, bu
134.
by Kalanos 3y ago
sounds like you've never done hard manual labor
135.
by Kalanos 3y ago
sorry about your wife. an immunostimulant is more about enraging/activating the immune system, not intervening with its capabilities
136.
by Kalanos 3y ago
even within the same type of tissue, different patients are going to have different mutations/subclones in their tumors.
137.
by Kalanos 3y ago
i wouldn't refer to it an an immunostimulant. it prevents tumors from hiding.
138.
by Kalanos 3y ago
thanks. yeah i dunno then First-line nivolumab metastatic colorectal w MMR: https://pubmed.ncbi.nlm.nih.gov/34637336/ first-line keytruda metastatic colorectal w MMR: https://www.nejm.org/doi/full&
139.
by Kalanos 3y ago
checkpoint inhibitors are antibodies
140.
by Kalanos 3y ago
It's a checkpoint inhibitor. Those have been used for ~ every cancer type for over a decade. Keytruda has been a top-selling drug for years. It looks like this trial was neoadjuvant (before treatment/ alternative to chemo and surg
141.
by Kalanos 3y ago
Many groundbreaking research papers are written by researchers at Chinese institutes
142.
by Kalanos 3y ago
teeming*
143.
by Kalanos 3y ago
is there no stem cell therapy/ clinical trial for this condition?
144.
by Kalanos 3y ago
inside a lymph node is the very last place i would expect a transplant. they are teaming with immune cells that should be hostile to an inter-species transplant. there are no red blood cells for oxygen, just lymph fluid. how would it recrui
145.
by Kalanos 3y ago
ah, okay. the opening paragraphs don't read like an RFC
146.
by Kalanos 3y ago
Has the opportunity for harmony between open source infrastructure and commercial cloud passed? the infrastructure for most software engineering projects already exists. could some kind of antitrust lawsuit force clouds to contribute a fair
147.
by Kalanos 3y ago
he wasn't a founder, and they were a bunch of rich boys from harvard.
148.
by Kalanos 3y ago
i've done this. i used to be the business guy. it works for a time, but not sustainable
149.
by Kalanos 3y ago
as a technical cofounder, i would highly recommend getting a business cofounder to handle fundraising, sales, and partnerships. business/people move slow... you can't muscle your way through it. you need like 5 high-quality opport
150.
by Kalanos 3y ago
which startups have you founded and made profitable? it's really scrappy through pre-seed if you can get one. software is the easy part

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