Kalanos

8 ms·

61.
by Kalanos 2y ago
I used sqlalchemy once. I found it more complicated with way less functionality
62.
by Kalanos 2y ago
People focus too much on the query aspect of an ORM. Even though you can still write raw query strings in an ORM if you want to. Routes, form validation, REST API, templating (if you don't need react), auth, etc. You'll probably w
63.
by Kalanos 2y ago
Lol. As if different tools for filtering rows/columns determines a programmer's capability.
64.
by Kalanos 2y ago
I've only heard about Ibis maybe three times in the past two years and I pay pretty close attention to the space. If Ibis moves away from pandas, then it just means that I am less likely to try Ibis because there is no bridge. Sure, hi
65.
by Kalanos 2y ago
i thought there already was a ruby kernel. are you the original developer or a new maintainer of iruby?
66.
by Kalanos 2y ago
My 2014 pro is still going strong
67.
by Kalanos 2y ago
https://youtu.be/BNWpZ-Y_KvU?si=0ANC62CFyCt8vLFW&t=99
68.
by Kalanos 2y ago
Perhaps because bacteria have no nucleus to protect their DNA and less DNA-damage repair mechanisms?
69.
by Kalanos 2y ago
Luck is a matter of time and networking. If you do the right stuff, eventually you will get lucky.
70.
by Kalanos 2y ago
so? most founders are doing that without pay, without a budget, and (most importantly) without the credibility that comes from the org/lab/prof
71.
by Kalanos 2y ago
In biotech, this is an understatement. PhD's get to develop stuff for years using university funds while on a salary.
72.
by Kalanos 2y ago
I know that I can achieve anything I put my mind to. I feel like I can shoot lightning from my hands and I wield 2 lightsabres. However, as a primarily computational and business-oriented founder, I am trying to disrupt an industry that is
73.
by Kalanos 2y ago
LOL "Psychological Factors: No plan B + Unlimited self-belief + History of feeling like an imposter"
74.
by Kalanos 2y ago
interesting. strings was supposed to be one of arrow's big features in comparison to numpy, right?
75.
by Kalanos 2y ago
I doubt step #1. When you downregulate mTOR, there are other supervisors of that pathway that help right the ship by upregulating it. It's naive to think "we can shut off one of the most critical pathways in biology"
76.
by Kalanos 2y ago
all drugs "temporarily silence genes" by acting on the gene's target protein until the dose degrades. silencing typically refers to siRNA/RNAi. There are only 7 siRNA approved, all for liver diseases
77.
by Kalanos 2y ago
So what? They could have payed someone to do that. They should focus on the user experience, not chips. For example, they let Siri languish for decades. Apple was glued to the hands/eyes of consumers, but neglected to train an AI/
78.
by Kalanos 2y ago
Thanks for the review. Surprised not to see any mention of interleukins and metformin. [Warning - metformin linked to birth defects] https://www.nature.com/articles/s41586-024-07701-9 The more I learn about molecular b
79.
by Kalanos 2y ago
Apple bet big on proprietary ARM chips, but now Qualcomm has commoditized this space. Apple followed Meta into VR/AR without a killer app.
80.
by Kalanos 2y ago
The tools associated with every file type you support have to support reading/writing a buffer/bytestream or whatever it is called. For example, `pd.read_parquet` accepts "file-like objects" as its first argument: https
81.
by Kalanos 2y ago
stop making personal attacks. i'm sure your suggestion exhibits creative step-one thinking, but i've described several reasons why it doesn't make sense to recreate a filesystem in sqlite, the combination of which should make
82.
by Kalanos 2y ago
just a string field that points to the file path
83.
by Kalanos 2y ago
cool. i don't want to recreate a filesystem in my app logic
84.
by Kalanos 2y ago
That sounds nice for chunking, but what if you need contiguous memory? E.g. viewing an image or running an AI model
85.
by Kalanos 2y ago
To make it more queryable, you can have different classes for dataset types with metadata like: file_format, num_files, sizes
86.
by Kalanos 2y ago
TLDR; don't do it. I've used SQLite blob fields for storing files extensively. Note that there is a 2GB blob maximum: https://www.sqlite.org/limits.html To read/write blobs, you have to serialize/deseria
87.
by Kalanos 2y ago
My sources are leading immuno-oncology pharma R&D teams and oncology VCs as recently as this week. I am launching an immuno-oncology therapeutics company.
88.
by Kalanos 2y ago
Yet investors and big pharma are both running away from immuno-oncology
89.
by Kalanos 2y ago
can't*
90.
by Kalanos 2y ago
woah woah woah. can you please phrase that as "try to earn more and try to spend less" we don't want to offend anyone here

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