ImaCake

52 ms·

541.
by ImaCake 5y ago
The press release is much more reader friendly than this re-report of it. https://www.pfizer.com/news/press-release/press-release-deta...
542.
by ImaCake 5y ago
Wikipedia suggests they first tried it on a lethal cat coronavirus. And the enzyme it inhibits, 3CL, is found in all coronaviriae. So one suspects this works against most coronaviruses.
543.
by ImaCake 5y ago
It is sad and unfortunately needed. You will note they stopped this study at the first “interim analysis”. One of the really important reasons such interim analyses are done is precisely to stop a trial when it so obviously works. They then
544.
by ImaCake 5y ago
In brief, coronaviruses make all their proteins as one long chain and then cut it up into the appropriate pieces to form the proteins (spike etc). 3CL protease is the cutting machine and Paxlovid inhibits that.
545.
by ImaCake 5y ago
I am at 30 and the last year has felt just as long as 2011 did for me. I've been seeing these articles and comments about time speeding up since my teens and I am still waiting for it to happen to me. I am inclined to think the percept
546.
by ImaCake 5y ago
Same approach I take in a research group in computational biology. Our datasets are often around the ~1-10 million rows range so those get processed in R or the command line. But often the summary analysis fits into a single page in excel.
547.
by ImaCake 5y ago
I’ve seen similar scenes driving in north western australia. The immensity of the flat desert landscape is something else.
548.
by ImaCake 5y ago
While it is sometimes true that larger sample sizes can overcome many insufficiencies in the data I don’t think that is the case here. The data is still noisy and any attempt at statistics here would result in a non-significant result. The
549.
by ImaCake 5y ago
Wow this paper is a joke. I see multiple conclusions drawn from insignificant statistical tests (if you can’t reject the null you can only say “i can’t see it”, not “its not there”). That alone should be enough to stop reading. There appear
550.
by ImaCake 5y ago
In certain countries having a specific flag come up on your reddit feed is dangerous. So NSFW applies to things like that too. I agree with your opinion on how reddit deals with NSFW issues.
551.
by ImaCake 5y ago
I am not convinced this is actually true. GMOs in practice tend to be the introduction of a foreign gene into an organism. Breeding is different; you shuffle ~1 million small effect size variants around and see if you can get a combination
552.
by ImaCake 5y ago
I am always happy to defend an advertisement that has informative content and is up front about it’s true nature as an ad. An honest ad would be a win-win, consumers understand things more and the product, if its good, gets increased sales
553.
by ImaCake 5y ago
Thanks, I am glad to know my half finished Masters degree isn’t a total waste :)
554.
by ImaCake 5y ago
This is it for me to. I have tried so many times to jump to linux and it never works out. I mostly use macOS for unix stuff because it works without breaking all the time. Windows for gaming and some light terminal use in WSL.
555.
by ImaCake 5y ago
If you are going to downvote me please explain to me why I am wrong. I am training to be a biostatistician so it is of professional interest to know if I have failed to explain something correctly or coherently.
556.
by ImaCake 5y ago
Placebo is controlled for in these kinds of experiments by using a comparison group exposed to a carefully designed placebo. To be very clear, you can test for the abscence of an effect. It is a little bit more challenging than finding a
557.
by ImaCake 5y ago
It is an anecdote but I also much prefer redshifting all my displays. At this point, it is really uncomfortable to look at a blue screen on someone's phone. If the science isn't finding an effect, they are either not measuring the
558.
by ImaCake 5y ago
The study merely finds no significance difference. Which does not equate to no effect. More participants could have led to a significant difference. If the authors wanted to claim that there was no significant difference they can perform an
559.
by ImaCake 5y ago
The parent comment is valuable, but the numbers do seem wrong. I think it is part of the argument for ending strict lockdowns once vaccination rates are high.
560.
by ImaCake 5y ago
A little bit of knowledge about stats and the appropiate language helps make this exercise easier. The R language is good at this kind of simulation. It comes with a whole bunch of random number generators out of the box. Here is how to est
561.
by ImaCake 5y ago
That is pretty neat! I have a dice stats python script I use specifically for DnD. It has command line flags and basically the same syntax as the discord dice bot. Very useful when you are considering strategy, even though my group plays fa
562.
by ImaCake 5y ago
Absolutely. I do note we have had a pretty big uptake on influenza vaccines through the pandemic so that should blunt the impact a little.
563.
by ImaCake 5y ago
It actually appears that influenza is very close to extinct in Australia for now. It will be interesting to see if influenza returns with the opening of borders this summer. >There has not been a death certified due to influenza in the f
564.
by ImaCake 5y ago
NZ is doing some impressive things in conservation. If there is any country on earth that can clear out most pest species, then it is NZ. It would be the combination of wealth and the isolated geopgraphy if you do pull it off.
565.
by ImaCake 5y ago
I have worked as a research assistant in two labs in different areas of medical biology. Much of what I do is act as a helper and interface for the PhD students and PostDocs. There is a lot of diversity in PhD students! They also face som
566.
by ImaCake 5y ago
Number 2 is huge for anyone considering the option of a PhD. My supervisors did not have a good track record and it is likely this is why my PhD burnt out into a Masters. They were amazing people, smart and hard working, but they just had n
567.
by ImaCake 5y ago
I like the sentiment of this comment, but I think it is a little too black and white. I am in science, so your mileage may vary. I have found a little bit of pro-activity on things you like to do anyway is a good way to turn your job into t
568.
by ImaCake 5y ago
For those not from Australia; we are not about to become a fascist state. The parent comment’s other complaints about inequality are indeed true and our government has failed them. Lockdown sucks and is problematic. There are riots and the
569.
by ImaCake 5y ago
I agree this needs an editor. It is hard to follow. I can forgive anyone in Australia for being frustrated right now. We have done really well against COVID but the two largest states are in lockdown until vaccination rates get high enoug
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by ImaCake 5y ago
Heh good point. Maybe its proximity has helped it become important, or it could be an accident of geography.

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