HedonicEscal8r

5 ms·

31.
by HedonicEscal8r 3mo ago
If you are 11 and wait 7 years to get a tattoo, your tattoo will look just as good or better. If you are 11 and wait 7 years to transition, you will suffer irreversible physical and psychological damage. You will have missed formative socia
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by HedonicEscal8r 3mo ago
> It’s literally irreversible damage when you mess up with hormones while on puberty. This is equally true when you don't intervene. The children being recruited for this study would otherwise be forced to undergo physical changes t
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by HedonicEscal8r 3mo ago
I think this is a failure of empathy. "Being unable to transition before a certain age" in this context entails a child having their body modified against their will, which they can only partially correct through expensive and avo
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by HedonicEscal8r 3mo ago
Which is also wrong. People living with BIID are (usually) not irrational. The small percentage that do seek amputation have usually exhausted all treatment options, and find that amputation improves their quality of life.
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by HedonicEscal8r 3mo ago
Yes, tanning is downstream of the activity of the p53 tumor suppressor protein in response to UVB-induced damage: https://www.lesswrong.com/posts/EFiCGc3YwadZBzvZ3/contra-byr...
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by HedonicEscal8r 3mo ago
Surely you would not be confused by "Place the word Madagascar in a way that makes no sense."
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by HedonicEscal8r 3mo ago
1. While it's difficult to put a number on exactly what % of the time this is true, depression is not always, and I would say not often, a situational problem. For almost every depressed person, there's a happy person living the s
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by HedonicEscal8r 3mo ago
Yup, and IP theft is morally good. Are we not on HackerNews?
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by HedonicEscal8r 3mo ago
I agree, sounds suspicious and likely misremembered.
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by HedonicEscal8r 3mo ago
She had Snijders Blok-Campeau syndrome, which is caused by mutations in the CHD3 protein, which manages the structure of DNA. In her case, it was this missense variant: https://www.ncbi.nlm.nih.gov/clinvar/variation&#x2
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by HedonicEscal8r 3mo ago
> May be such infusion would really serve as a vaccine prepping the immune system for the main infusion later? This is correct and exactly the problem. You don't want the immune system to react to the virus, but giving it exposure
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by HedonicEscal8r 3mo ago
Malignant hyperthermia?
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by HedonicEscal8r 3mo ago
There are many children with life-threatening rare diseases that would be much better candidates for risky experimental treatment like this. Very sad case.
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OpenAI CEO of Applications Fidji Simo steps down due to chronic illness(twitter.com)
1 points by HedonicEscal8r 3mo ago|1 comments
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by HedonicEscal8r 3mo ago
Fidji Simo didn't disclose what condition she suffers from. In 2025, she co-founded ChronicleBio, which aims to accelerate progress on POTS, ME/CFS, Long COVID, and other neuroimmune disorders. Lots of people suffer from unexplain
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by HedonicEscal8r 4mo ago
I know someone who knew such a women that benefited from this suggestion, so for what it's worth: women who feel strongly about having kids but are struggling to find a suitable partner should consider instead finding a suitable sperm
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by HedonicEscal8r 4mo ago
By the 23rd century, sexual reproduction will be vastly transformed by technology. The discussions we're having now will be unrecognizable.
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by HedonicEscal8r 4mo ago
It depends on browser defaults. On Brave and Chrome, I don't see serifs, and on Firefox I do.
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The LLM shoggoth meme is weirder than you think(hedonicescalator.substack.com)
4 points by HedonicEscal8r 4mo ago|0 comments
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by HedonicEscal8r 4mo ago
GLP-1s are far more effective than statins.