88e282102ae2e5b

10 ms·

61.
by 88e282102ae2e5b 9y ago
All known CRISPR systems work only under very specific conditions. You could drink a vial of Cas9 and it wouldn't do anything to you because it couldn't enter your cells.
62.
by 88e282102ae2e5b 9y ago
These differences appear quite small. It would really benefit from just having error bars, or any kind of significance test.
63.
by 88e282102ae2e5b 9y ago
It conveys intent better. The function name is effectively a way of documenting what the result of np.mean should be interpreted as. xval is a terrible name, but it does make it easier to see what's being passed into np.mean.
64.
by 88e282102ae2e5b 9y ago
Does scikit-image have the algorithms you need? If so, I'd highly recommend it for image processing - the API and documentation are well done.
65.
by 88e282102ae2e5b 10y ago
I think it might be better to say that contemporary psychology is frequently not being performed scientifically.
66.
by 88e282102ae2e5b 10y ago
This is exactly like every other linear algebra book I've ever seen, other than the title. I was hoping this had been improved over v1 but it seems to be unchanged in any significant way. What exactly does the author think the bullshit
67.
by 88e282102ae2e5b 10y ago
Well, it's not really a problem now. Spring came a month early, but who cares? Islands aren't underwater yet, there's plenty of food in first world countries (who would be paying for this) and there's no serious drought.
68.
by 88e282102ae2e5b 10y ago
I went back to school for a biochemistry PhD after a few years as a web developer - no regrets, though I do miss not being broke. Computers are still vitally important to my career though and HN serves as a convenient aggregator of programm
69.
by 88e282102ae2e5b 10y ago
> Every time I see an article like this I wonder why it hasn't already happened Evolution, unfortunately, ruins all the fun. Producing all those proteins to make your drug of choice puts a large burden on the cells - any of them tha
70.
by 88e282102ae2e5b 10y ago
Honestly, an introductory biology textbook is your best bet. But other response is correct: we can't even simulate a single protein well, much less an entire organism.
71.
by 88e282102ae2e5b 10y ago
Sure, but I'm less worried about absolute rank and more interested in whether the language I'm using is on the order of C/C++/Fortran. I can sell a 2x slowdown to my boss if I can show that that's the only cost of a
72.
by 88e282102ae2e5b 10y ago
What DO you do if someone mails you heroin? Is the only reason he's not in jail the fact that he snuck into the forum and uncovered the plot before it happened?
73.
by 88e282102ae2e5b 10y ago
You're very much correct, but I'm almost glad I got hoodwinked. I've debated whether I'm handicapping myself by sticking with Python and Rust, but reading through this list I was just aghast at how many problems I didn&#
74.
by 88e282102ae2e5b 10y ago
This reminds me a lot of some of the first home movies that were made, where people would just stand completely still in front of the camera, as they didn't really understand what the new device was capable of.
75.
by 88e282102ae2e5b 10y ago
That's true, but my argument is that we can basically guarantee that a simple neural net won't become self-aware, in the same way that we know that a linear regression library won't become self-aware. The complexity is bounde
76.
by 88e282102ae2e5b 10y ago
Well, the actual names of the base pairs they used are dNaM, d5SICS and dTPT3. It doesn't seem to me there are any good choices.
77.
by 88e282102ae2e5b 10y ago
It can replicate them, but the XY pairs are just in a plasmid and not in the genome of the bacteria. They were chosen because natural polymerases could use them. However, there are no corresponding RNA unnatural bases, and there's no t
78.
by 88e282102ae2e5b 10y ago
The paper specifically states that these unnatural base pairs were chosen because they can be handled by natural polymerases. Also, the only way to maintain a plasmid over time is to replicate it. In fact, the whole logic of the strategy is
79.
by 88e282102ae2e5b 10y ago
Definitely interesting work, and some very clever solutions to difficult problems, but to be clear, they only had a single unnatural base pair, and it was only in a plasmid. Addressing the other comments about this leading to some crazy sci
80.
by 88e282102ae2e5b 10y ago
It's like I accidentally stuck my hand in a running blender and someone asks whether I'm angry because of the noise of the motor or because the buttons aren't arranged in a reasonable order. I tried learning about Haskell jus
81.
by 88e282102ae2e5b 10y ago
Once I had learned the syntax, it took me a few days while working on a real project with well-defined goals to internalize the borrow-checker and such. Clippy has also been a surprisingly useful tool for learning - it pointed out some thin
82.
by 88e282102ae2e5b 10y ago
Xubuntu - beautiful, clean and simple, and none of the bloat and weirdness of vanilla Ubuntu.
83.
by 88e282102ae2e5b 10y ago
Comforting shareholders is one potential reason.
84.
by 88e282102ae2e5b 10y ago
It might just be as simple as $200 being a lot of money to the attacker.
85.
by 88e282102ae2e5b 10y ago
Ah yes, I should have stated that the object is immutable.
86.
by 88e282102ae2e5b 10y ago
I think a problem with this is that when you bring an actual database into the test, it ceases to be a unit test and becomes an integration test (not that integration tests aren't useful). I would prefer for the application to be separ
87.
by 88e282102ae2e5b 10y ago
If I have some object I want to test in multiple ways, I find it more convenient to create a single instance during setup and then testing various aspects of just that single instance. Since the constructor of the object in question needs a
88.
by 88e282102ae2e5b 10y ago
Yes, though I break it up into different (labelled) sections, so I don't have a large number of files. It may just work for me since I tend to write longish overviews of things (papers, concepts, experiments, etc.).
89.
by 88e282102ae2e5b 10y ago
There is at least some value in filtering low-quality submissions, wrangling reviewers, and making editorial decisions when reviewers disagree or are just being assholes (e.g. attempting to hinder a competitor).
90.
by 88e282102ae2e5b 10y ago
I use Jupyter notebooks and write in markdown.

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