It depends on the lag compensation of the game in question. For instance, in league of legends, you can't do a few champion combos (like Alistar's headbutt + pu

It depends on the lag compensation of the game in question. For instance, in league of legends, you can't do a few champion combos (like Alistar's headbutt + pulverize) on a lag greater than 200ms. But enemy skills register just fine. Packet loss is even more awful when your skills don't register or you don't know what's going on for a second or two. This does puts the players at an unfair disadvantage.