2 ms·

Thanks for the references 1 and 2. I had no idea that curcumin was a mitochondrial uncoupler. Incidentally, I was looking at curcumin to help with my mitochondr

by fasteo 11y ago

Thanks for the references 1 and 2. I had no idea that curcumin was a mitochondrial uncoupler. Incidentally, I was looking at curcumin to help with my mitochondrial myopathy, but for its anti-inflammatory effects - I have a really hard time to recover from my workouts possibly due to a systemic inflammatory response caused by my genetic condition. I have always thought that low-dose DNP would be a potentially good treatment for mitochondrial myopathies, as they induce mitochondrial biogenesis [1], but DNP can be dangerous and I have been hesitant to try it. Maybe I just need to add curcumin to my current supplements regime. [1] Caldeira da Silva, C. C., Cerqueira, F. M., Barbosa, L. F., Medeiros, M. H., & Kowaltowski, A. J. (2008). Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity. Aging cell, 7(4), 552-560.

Toast_ 11y ago
Any uncoupler ought to induce mitochondrial biogenesis, as it's a systemic response due to a lack of energy (I may be mistaken?)—same goes for [vascular] endothelial growth factor and EPO (just to name a few). Also, I really can't recommend reading the paper associated with the third link enough. Have you tried ephedrine to help with the post-workout swelling? The common 'ECA' stack might be right up your alley.
- fasteo 11y ago
  >>> Also, I really can't recommend reading the paper associated with the third link enough. Just read it. Very interesting indeed. >>>Have you tried ephedrine to help with the post-workout swelling? The common 'ECA' stack might be right up your alley. Do you have any reference for this ? What is the mechanism of action ?