4 ms·

Peptide-1 Suppresses High-Fat Food Intake by Reducing Synaptic Drive

13 points by ycnews 11y ago

ycnews 11y ago
Less technical article (which links to the above) here: http://www.washingtonpost.com/news/to-your-health/wp/2015/07/24/overeating-may-be-caused-by-a-hormone-deficiency-scientists-say/ http://www.washingtonpost.com/news/to-your-health/wp/2015/07...
- dlo 11y ago
  This is a cool paper. I'm saddened that there is not much discussion on it. It may be too jargon-laced. The above WaPo article takes away too much, and in my opinion, makes the topic less interesting. If there is interest, I can take a stab at writing an explanation of this result for the technical person, such as those here on HN, who is uninitiated to the field.
  - smartial_arts 11y ago
    That would be fantastic - and admittedly people like yourself or some other folks I can think of (Paul Whiteley of "Questioning Answers" fame comes to mind) are doing really great job on explaining the complex subjects in lay terms. Please do this!
CuriouslyC 11y ago
For those that are interested, one of the metabolites produced during bacterial fermentation of fiber, butyrate, has been shown to stimulate GLP-1 secretion (http://www.jbc.org/content/288/35/25088.short http://www.jbc.org/content/288/35/25088.short) and furthermore acts as a PPAR-gamma agonist, which has been linked to improved insulin sensitivity and reduced visceral fat accumulation through up-regulation of adiponectin production. All you need to do in order to reap these benefits is consume the right kind of fermentable carbohydrates. In particular, resistant starch and most forms of soluble fibers work fairly well. Beans (particularly lentils and split peas) are great, as are flax/chia seeds. You can also buy a modified corn starch called Hi-Maize that is about 60% resistant starch. If you experience issues with gas/bloating, I've found it helps to consume live-cultured food (raw fermented vegetables or yogurt/kefir) once or twice a day.
- fasteo 11y ago
  I usually take unmodified potato starch[1]. It took me about a month to get used to it, in terms of gas/bloating, but definitively, it is doing something in my brain (much less hunger) [1] http://www.amazon.com/Bobs-Red-Mill-Potato-24-Ounce/dp/B004VLVCGU http://www.amazon.com/Bobs-Red-Mill-Potato-24-Ounce/dp/B004V...
  - smartial_arts 11y ago
    Although this is very tangentially related, one may want to consider taking a multi-species probiotic also, based on "A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood" [1]: "Compared to participants who received the placebo intervention, participants who received the 4-week multispecies probiotics intervention showed a significantly reduced overall cognitive reactivity to sad mood, which was largely accounted for by reduced rumination and aggressive thoughts. Conclusion: These results provide the first evidence that the intake of probiotics may help reduce negative thoughts associated with sad mood. Probiotics supplementation warrants further research as a potential preventive strategy for depression." [1] http://www.sciencedirect.com/science/article/pii/S0889159115000884 http://www.sciencedirect.com/science/article/pii/S0889159115...

13 points by ycnews 11y ago

Less technical article (which links to the above) here: http://www.washingtonpost.com/news/to-your-health/wp/2015/07/24/overeating-may-be-caused-by-a-hormone-deficiency-scientists-say/ http://www.washingtonpost.com/news/to-your-health/wp/2015/07...

dlo 11y ago
This is a cool paper. I'm saddened that there is not much discussion on it. It may be too jargon-laced. The above WaPo article takes away too much, and in my opinion, makes the topic less interesting. If there is interest, I can take a stab at writing an explanation of this result for the technical person, such as those here on HN, who is uninitiated to the field.
- smartial_arts 11y ago
  That would be fantastic - and admittedly people like yourself or some other folks I can think of (Paul Whiteley of "Questioning Answers" fame comes to mind) are doing really great job on explaining the complex subjects in lay terms. Please do this!

CuriouslyC 11y ago

For those that are interested, one of the metabolites produced during bacterial fermentation of fiber, butyrate, has been shown to stimulate GLP-1 secretion (http://www.jbc.org/content/288/35/25088.short http://www.jbc.org/content/288/35/25088.short) and furthermore acts as a PPAR-gamma agonist, which has been linked to improved insulin sensitivity and reduced visceral fat accumulation through up-regulation of adiponectin production. All you need to do in order to reap these benefits is consume the right kind of fermentable carbohydrates. In particular, resistant starch and most forms of soluble fibers work fairly well. Beans (particularly lentils and split peas) are great, as are flax/chia seeds. You can also buy a modified corn starch called Hi-Maize that is about 60% resistant starch. If you experience issues with gas/bloating, I've found it helps to consume live-cultured food (raw fermented vegetables or yogurt/kefir) once or twice a day.

fasteo 11y ago
I usually take unmodified potato starch[1]. It took me about a month to get used to it, in terms of gas/bloating, but definitively, it is doing something in my brain (much less hunger) [1] http://www.amazon.com/Bobs-Red-Mill-Potato-24-Ounce/dp/B004VLVCGU http://www.amazon.com/Bobs-Red-Mill-Potato-24-Ounce/dp/B004V...
- smartial_arts 11y ago
  Although this is very tangentially related, one may want to consider taking a multi-species probiotic also, based on "A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood" [1]: "Compared to participants who received the placebo intervention, participants who received the 4-week multispecies probiotics intervention showed a significantly reduced overall cognitive reactivity to sad mood, which was largely accounted for by reduced rumination and aggressive thoughts. Conclusion: These results provide the first evidence that the intake of probiotics may help reduce negative thoughts associated with sad mood. Probiotics supplementation warrants further research as a potential preventive strategy for depression." [1] http://www.sciencedirect.com/science/article/pii/S0889159115000884 http://www.sciencedirect.com/science/article/pii/S0889159115...