I'm going to start with a fact that you likely won't want to hear: There is no magic bullet. Non-situational depression is something you will wrestle with you

I'm going to start with a fact that you likely won't want to hear: There is no magic bullet. Non-situational depression is something you will wrestle with your entire life. There is no cure, only treatments. That said, you can do a lot to alleviate the symptoms. Ranked in order of importance: 1. Sleep Get good sleep. Research circadian rhythms, and try to understand your own 'sleep physiology'. Within the constraints of your work, try and sleep at optimal times for YOU. For me, going to bed late, waking up late, is best. I feel more rejuvenated on 4 hours of sleep within my 'sleep window' than I do of 8 hours of sleep outside of it. Find what works for you. 2. Intense, social, exercise. Other's have mentioned cross fit, but boxing is great too. It has to be INTENSE and there needs to be a SOCIAL component to keep you motivated. You should leave your workout feeling completely destroyed. In my opinion, just going to the gym doesn't work. You need to be part of a fitness community. The social aspect, combined with the intense workout, can work wonders. Go regularly. 3. Diet. Avoid junk food. Cut out hard drugs, obviously. Cook for yourself, if you can. 4. Purpose. Find something in life that excites you, and pursue it. Find a community of people that are also interested in that and join that community. Contribute to that community, whenever you can. Form relationships with others in that community, as you pursue your passion. ---- Discipline, and regularity, are vital to success. If you do these 4 things, you'll find with time, that your depression weakens it's grip on you. Be patient with point number 4. Don't be discouraged, if right now, you don't have a calling, or a purpose. Let life happen, and go where the wind blows.