Coffee (but not necessarily caffeine) has been linked to elevated homocysteine which is associated with cardiovascular disease. One such study: http://ajcn.nutr

Coffee (but not necessarily caffeine) has been linked to elevated homocysteine which is associated with cardiovascular disease. One such study: http://ajcn.nutrition.org/content/76/6/1244.full http://ajcn.nutrition.org/content/76/6/1244.full