Was the email you're replying to connected to the issue you're discussing? If yes (e.g. Support Forum message), then no-reply is a bad UX and it absolutely sho

Was the email you're replying to connected to the issue you're discussing? If yes (e.g. Support Forum message), then no-reply is a bad UX and it absolutely should connect to an appropriate channel like posting the response to the thread. If not (e.g. Marketing email), you're probably trying to talk to the wrong person anyway. Besides, having a person in marketing sifting through all those emails to try and find relevant emails is imperfect and slow with the chances of signal getting lost in the noise highly likely.