3 ms·

Saw an interesting and relevant discussion in this thread earlier today: https://news.ycombinator.com/item?id=9877773 https://news.ycombinator.com/item?id=98777

by boyaka 11y ago

Saw an interesting and relevant discussion in this thread earlier today: https://news.ycombinator.com/item?id=9877773 https://news.ycombinator.com/item?id=9877773 The user willholloway seems to have quite a bit of experience (using deprenyl/azilect as opposed to amphetamines to prevent neurodegeneration) and is touting a new "small-molecule drug", NSI-189, as a future major treatment for "depression, ptsd, and other neurodegenerative disorders." Edit: whatdya know, he posted here as I was typing this.

willholloway 11y ago
I know how skeptical and cynical HN can be, so I thought I should add that while I've become an evangelist, it isn't me that is claiming NSI-189 as a treatment for depression and ptsd, its the maker Neuralstem, and it's backed up by autopsied rats whose hippocampus grew 20% in size after the drug was administered. Here is an interesting blog post from the maker about NSI-189 and NZT from the movie limitless. http://www.neuralstem.com/neuralstem-ceo-blog/86-i-cant-give-you-brains-but-i-can-give-you-a-diploma http://www.neuralstem.com/neuralstem-ceo-blog/86-i-cant-give... I think NSI is such a cool story because besides perhaps rescuing millions of people from the despair of PTSD, it is so similar to the concept of NZT in Limitless. And just like in Limitless, it is not easy to procure at the moment.
- mb0 11y ago
  Did you experience major depression prior to taking the drug, or have you talked to any major depressive people who also tried the drug? Have you experienced any negative side effects from the drug, or talked to anyone who experienced negative side effects? I am pretty cautious about trying new drugs, as some currently legal drugs can carry dangerous side effects (ie: viibryd causing brain shocks in active patients).
  - boyaka 11y ago
    Note that a similar question was asked in the thread I linked: https://news.ycombinator.com/item?id=9880661 https://news.ycombinator.com/item?id=9880661 Not that it would hurt to discuss it further here.
  - deleted 11y ago
    [deleted]
  - willholloway 11y ago
    No major depression, just work related burn out and the ordeal of coming of age during the Bush administration.

by boyaka 11y ago

willholloway 11y ago

I know how skeptical and cynical HN can be, so I thought I should add that while I've become an evangelist, it isn't me that is claiming NSI-189 as a treatment for depression and ptsd, its the maker Neuralstem, and it's backed up by autopsied rats whose hippocampus grew 20% in size after the drug was administered. Here is an interesting blog post from the maker about NSI-189 and NZT from the movie limitless. http://www.neuralstem.com/neuralstem-ceo-blog/86-i-cant-give-you-brains-but-i-can-give-you-a-diploma http://www.neuralstem.com/neuralstem-ceo-blog/86-i-cant-give... I think NSI is such a cool story because besides perhaps rescuing millions of people from the despair of PTSD, it is so similar to the concept of NZT in Limitless. And just like in Limitless, it is not easy to procure at the moment.

mb0 11y ago
Did you experience major depression prior to taking the drug, or have you talked to any major depressive people who also tried the drug? Have you experienced any negative side effects from the drug, or talked to anyone who experienced negative side effects? I am pretty cautious about trying new drugs, as some currently legal drugs can carry dangerous side effects (ie: viibryd causing brain shocks in active patients).
- boyaka 11y ago
  Note that a similar question was asked in the thread I linked: https://news.ycombinator.com/item?id=9880661 https://news.ycombinator.com/item?id=9880661 Not that it would hurt to discuss it further here.
- deleted 11y ago
  [deleted]
- willholloway 11y ago
  No major depression, just work related burn out and the ordeal of coming of age during the Bush administration.