3 ms·

Yes, completely preventive. I have two family members who developed it in their 70's. I am 30. Update because I can't reply re: self-experimenting: Deprenyl

Yes, completely preventive. I have two family members who developed it in their 70's. I am 30. Update because I can't reply re: self-experimenting: Deprenyl is an incredibly well researched molecule, with a great safety profile. We also have a lot of reason to suspect amphetamines like adderall are neurotoxic to dopamine neurons, and hence my fervent belief that deprenyl should be a first line treatment for those wishing for enhanced focus, and amphetamines should be reserved for tougher cases.

feld 11y ago
Interesting. My dad was diagnosed young, but I don't have any of the Parkinsons markers according to 23andMe My dad has submitted data to 23andMe as well, but unfortunately it didn't come with a free account. It was a special thing they were doing to collect Parkinson's data. So I have no idea if he has the markers.
- beggi 11y ago
  If you can get the data, you can put it through Promethease.com for $5 and check for markers
brianbreslin 11y ago
I have family members who had it, so I did the 23&me screening for it (negative on genetic mutation thankfully). Have you done that yet?
- willholloway 11y ago
  I have not done 23&me but really should. My gut feeling is that my family members were perhaps more susceptible than the general population but it was chronic stress & environmental insults that pushed them over the edge, hence the late onset. I have a very strong belief that Parkinson's will be completely cured by the time I could be at risk. It has been completely reversed in several animals with the use of a few different types of stem cells. I have also gotten my hands on a brand new neurogenic small-molecule drug called NSI-189 that is currently undergoing clinical trials. Originally commissioned by DARPA to create the war figher of the future, NSI-189 has shown a robust effect in triggering hippocampal stem cells to regrow the hippocampus. I've ingested about 5 grams and its had a tremendously positive effect on me.
  - biturd 11y ago
    Do you have a diagnosis of something wrong with you, are did you just start taking NSI-189? I was on a medication for 5+ years and it has taken it's tool on me, as well as getting off those meds was not simple. I still struggle with side effects that can take years to go away. What has NSI-189 done for you specifically and how does it make you feel? Are there any annoying side effects and where in the heck did you get it?
    - willholloway 11y ago
      No diagnosis, I got burned out at work, I pushed myself far past the time to take a vacation and find another job. I took a few months off and felt much better but not back like my old self in college. NSI made me feel like a kid again. Brought me back to 100%. Stress is really, really bad for our brains, particularly our hippocampus. No side effects for me. I got it through back channels, can't say anymore and risk the pipeline. It will be on the market in five years and will in my opinion revolutionize the treatment of depression, ptsd and other neurodegenerative disorders. Curious what medications you were taking?
      - fapjacks 11y ago
        Interesting. This is how I feel about MDMA wrt PTSD, which may very well also be on the market for medical use in the next ten or twenty years.
melling 11y ago
Since you're only in your 30's, wouldn't it be better to help raise money and awareness for a cure rather than experiment on your body? https://www.michaeljfox.org https://www.michaeljfox.org 30-40 years is a lot of time for research. Andy Grove is another famous person with the disease who's working hard to find treatments: http://www.forbes.com/forbes/2008/0128/070.html http://www.forbes.com/forbes/2008/0128/070.html
- kragen 11y ago
  You can _both_ fund further research _and_ apply the research that’s already been done. In fact, if you’re not going to apply the already existing research, what’s the point of funding more? Are you going to apply the new research but not the current research? And prevention is much cheaper than cure.
  - melling 11y ago
    Well, there's no guarantee that it will do anything. Over 30 years, taking a supplement may lead to other problems, or it may become less effective when you really need it. Personally, I'd probably wait until my early 50's. Hopefully, at the very least, in 20 years, they'll be able to detect and monitor the effects on the body with more precision. At the very least, billions more in research will have been done.
- jokr004 11y ago
  ..maybe, or 30-40 years from now we might not have made any progress, then what?
  - melling 11y ago
    Let me take you back 30 years... https://www.youtube.com/watch?v=EDhpcOJ2zzM https://www.youtube.com/watch?v=EDhpcOJ2zzM If you go back 40 years, the MRI wasn't even invented. In fact, there wasn't an Apple computer. The PC revolution was a few years away. A lot will change in 30 years. Whether we're 10 years from the singularity, perhaps not, but technology is increasing at a more rapid pace.
PlE 11y ago
With all due respect, hemp oil is safer, cheaper and more effective [1]: "What neuropathy is, is your nerve cells are starting to die. And it can occur in different places with different symptoms depending on what cells are dying. Things like, for example, Alzheimers is an obvious example of nerve cell death. Things like ALS. Things like Parkinsons disease. These are just all different formats, different disease states, that result from nerves dying. And our endocannabinoid system plays a very unique role in trying to protect us from various kinds of nerve cell death. So what's going on with the endocannabinoid system is that it's something that protects our nerves in general. It helps promote nerve growth and nerve health, and rewiring of your brain. You know, adults up until the fairly recent past, it was believed that we no longer had the capacity to regenerate nerves. And what we now know is that we do have that capacity, but furthermore what we know is that nerve regeneration in the brain is very much regulated by these marijuana-like compounds, these endocannabinoids. So we have a whole host of very important activities, the direct protection of nerves from dying, the promotion of regeneration, the promotion of learning, of re-learning things, is a very important biological effect of our endocannabinoid system. So what are the kinds of things we can do to try and promote health in these areas? On the one hand, everybody should make sure they take in enough essential fatty acids. And certainly I would say one of the best sources for that is we should be consuming hemp oil. And the reason I say hemp oil as opposed to fish oil is because you can ensure organic hemp oil is not contaminated with things like mercury. And that's going to allow our bodies to make our endocannabinoids. We often hear about the beneficial effects of things like Omega-3s and Omega-6s, and at least some of the attributes of those compounds are the result of them being converted into endocannabinoids. So at least that way your body can do what your body can do. You're giving it the tools to make the things that you need. But in many cases, that's not sufficient, and we have to supplement beyond what our body can make. And there's only one plant on the planet that has the capacity to mimic the way our body works with these endocannabinoids, and that's marijuana. So marijuana actually directly mimics these particular compounds, and as a result, it has these strong neuroprotectant effects. But because marijuana and these endocannabinoids, their activities are so pervasive in our bodies, they literally regulate every system in your body, your immune system, digestive system, reproductive system, cardiovascular system. Everything in your body is homeostatically maintained by endocannabinoids, meaning balance. They're how our body tries to balance how we interact with the environment when our environment becomes stressful for us, stressful psychologically, stressful biochemically. So these are very, very critical compounds and the use of cannabis can have a profound effect in terms of helping to stop nerve cell degeneration, helping restore functional nerves, helping restore new ways of thinking. And this is just really touching on the surface of the humongous number of benefits that this plant can have for so many different illnesses. ... and what our cannabinoids system is evolved to do over many hundreds of millions of years has been to protect us from those kinds of inbalances. To restore the kind of health that we need. And because of our environment, in particular because we are living longer, we need to be able to adapt very rapidly today, and we can't do that on an evolutionary scale. The way for us to do that as people, as intelligent people, is to make sure we're eating good diets, stay away from toxins, and eat these essential fatty acids, and when necessary, consume cannabinoids." - Dr. Bob Melamed, Ph.D., UC Colorado Springs http://www.uccs.edu/rmelamed/endocannabinoids-and-medical-marijuana/dr-bobs-video-links.html http://www.uccs.edu/rmelamed/endocannabinoids-and-medical-ma... http://www.youtube.com/watch?v=ZeeVBSERb-c http://www.youtube.com/watch?v=ZeeVBSERb-c [1] http://www.youtube.com/watch?v=XP5yxaVksbY http://www.youtube.com/watch?v=XP5yxaVksbY
TrevorJ 11y ago
Some of the metabolites of Deprenyl are amphetamines.

feld 11y ago

Interesting. My dad was diagnosed young, but I don't have any of the Parkinsons markers according to 23andMe My dad has submitted data to 23andMe as well, but unfortunately it didn't come with a free account. It was a special thing they were doing to collect Parkinson's data. So I have no idea if he has the markers.

beggi 11y ago
If you can get the data, you can put it through Promethease.com for $5 and check for markers

brianbreslin 11y ago

I have family members who had it, so I did the 23&me screening for it (negative on genetic mutation thankfully). Have you done that yet?

willholloway 11y ago
I have not done 23&me but really should. My gut feeling is that my family members were perhaps more susceptible than the general population but it was chronic stress & environmental insults that pushed them over the edge, hence the late onset. I have a very strong belief that Parkinson's will be completely cured by the time I could be at risk. It has been completely reversed in several animals with the use of a few different types of stem cells. I have also gotten my hands on a brand new neurogenic small-molecule drug called NSI-189 that is currently undergoing clinical trials. Originally commissioned by DARPA to create the war figher of the future, NSI-189 has shown a robust effect in triggering hippocampal stem cells to regrow the hippocampus. I've ingested about 5 grams and its had a tremendously positive effect on me.
- biturd 11y ago
  Do you have a diagnosis of something wrong with you, are did you just start taking NSI-189? I was on a medication for 5+ years and it has taken it's tool on me, as well as getting off those meds was not simple. I still struggle with side effects that can take years to go away. What has NSI-189 done for you specifically and how does it make you feel? Are there any annoying side effects and where in the heck did you get it?
  - willholloway 11y ago
    No diagnosis, I got burned out at work, I pushed myself far past the time to take a vacation and find another job. I took a few months off and felt much better but not back like my old self in college. NSI made me feel like a kid again. Brought me back to 100%. Stress is really, really bad for our brains, particularly our hippocampus. No side effects for me. I got it through back channels, can't say anymore and risk the pipeline. It will be on the market in five years and will in my opinion revolutionize the treatment of depression, ptsd and other neurodegenerative disorders. Curious what medications you were taking?
    - fapjacks 11y ago
      Interesting. This is how I feel about MDMA wrt PTSD, which may very well also be on the market for medical use in the next ten or twenty years.

melling 11y ago

Since you're only in your 30's, wouldn't it be better to help raise money and awareness for a cure rather than experiment on your body? https://www.michaeljfox.org https://www.michaeljfox.org 30-40 years is a lot of time for research. Andy Grove is another famous person with the disease who's working hard to find treatments: http://www.forbes.com/forbes/2008/0128/070.html http://www.forbes.com/forbes/2008/0128/070.html

kragen 11y ago
You can _both_ fund further research _and_ apply the research that’s already been done. In fact, if you’re not going to apply the already existing research, what’s the point of funding more? Are you going to apply the new research but not the current research? And prevention is much cheaper than cure.
- melling 11y ago
  Well, there's no guarantee that it will do anything. Over 30 years, taking a supplement may lead to other problems, or it may become less effective when you really need it. Personally, I'd probably wait until my early 50's. Hopefully, at the very least, in 20 years, they'll be able to detect and monitor the effects on the body with more precision. At the very least, billions more in research will have been done.
jokr004 11y ago
..maybe, or 30-40 years from now we might not have made any progress, then what?
- melling 11y ago
  Let me take you back 30 years... https://www.youtube.com/watch?v=EDhpcOJ2zzM https://www.youtube.com/watch?v=EDhpcOJ2zzM If you go back 40 years, the MRI wasn't even invented. In fact, there wasn't an Apple computer. The PC revolution was a few years away. A lot will change in 30 years. Whether we're 10 years from the singularity, perhaps not, but technology is increasing at a more rapid pace.

PlE 11y ago

With all due respect, hemp oil is safer, cheaper and more effective [1]: "What neuropathy is, is your nerve cells are starting to die. And it can occur in different places with different symptoms depending on what cells are dying. Things like, for example, Alzheimers is an obvious example of nerve cell death. Things like ALS. Things like Parkinsons disease. These are just all different formats, different disease states, that result from nerves dying. And our endocannabinoid system plays a very unique role in trying to protect us from various kinds of nerve cell death. So what's going on with the endocannabinoid system is that it's something that protects our nerves in general. It helps promote nerve growth and nerve health, and rewiring of your brain. You know, adults up until the fairly recent past, it was believed that we no longer had the capacity to regenerate nerves. And what we now know is that we do have that capacity, but furthermore what we know is that nerve regeneration in the brain is very much regulated by these marijuana-like compounds, these endocannabinoids. So we have a whole host of very important activities, the direct protection of nerves from dying, the promotion of regeneration, the promotion of learning, of re-learning things, is a very important biological effect of our endocannabinoid system. So what are the kinds of things we can do to try and promote health in these areas? On the one hand, everybody should make sure they take in enough essential fatty acids. And certainly I would say one of the best sources for that is we should be consuming hemp oil. And the reason I say hemp oil as opposed to fish oil is because you can ensure organic hemp oil is not contaminated with things like mercury. And that's going to allow our bodies to make our endocannabinoids. We often hear about the beneficial effects of things like Omega-3s and Omega-6s, and at least some of the attributes of those compounds are the result of them being converted into endocannabinoids. So at least that way your body can do what your body can do. You're giving it the tools to make the things that you need. But in many cases, that's not sufficient, and we have to supplement beyond what our body can make. And there's only one plant on the planet that has the capacity to mimic the way our body works with these endocannabinoids, and that's marijuana. So marijuana actually directly mimics these particular compounds, and as a result, it has these strong neuroprotectant effects. But because marijuana and these endocannabinoids, their activities are so pervasive in our bodies, they literally regulate every system in your body, your immune system, digestive system, reproductive system, cardiovascular system. Everything in your body is homeostatically maintained by endocannabinoids, meaning balance. They're how our body tries to balance how we interact with the environment when our environment becomes stressful for us, stressful psychologically, stressful biochemically. So these are very, very critical compounds and the use of cannabis can have a profound effect in terms of helping to stop nerve cell degeneration, helping restore functional nerves, helping restore new ways of thinking. And this is just really touching on the surface of the humongous number of benefits that this plant can have for so many different illnesses. ... and what our cannabinoids system is evolved to do over many hundreds of millions of years has been to protect us from those kinds of inbalances. To restore the kind of health that we need. And because of our environment, in particular because we are living longer, we need to be able to adapt very rapidly today, and we can't do that on an evolutionary scale. The way for us to do that as people, as intelligent people, is to make sure we're eating good diets, stay away from toxins, and eat these essential fatty acids, and when necessary, consume cannabinoids." - Dr. Bob Melamed, Ph.D., UC Colorado Springs http://www.uccs.edu/rmelamed/endocannabinoids-and-medical-marijuana/dr-bobs-video-links.html http://www.uccs.edu/rmelamed/endocannabinoids-and-medical-ma... http://www.youtube.com/watch?v=ZeeVBSERb-c http://www.youtube.com/watch?v=ZeeVBSERb-c [1] http://www.youtube.com/watch?v=XP5yxaVksbY http://www.youtube.com/watch?v=XP5yxaVksbY

TrevorJ 11y ago

Some of the metabolites of Deprenyl are amphetamines.