5 ms·

There is a much cleaner, and safer drug that can reduce the chance of developing Parkinson's, and that is Deprenyl [1]. > Deprenyl protects the nigrostriatal d

There is a much cleaner, and safer drug that can reduce the chance of developing Parkinson's, and that is Deprenyl [1]. > Deprenyl protects the nigrostriatal dopaminergic neurons against selective neurotoxins (6-hydroxydopamine, MPTP, DSP-4) [2] We know that environmental insults like solvent inhalation and most likely agricultural pesticides contribute to the loss of dopamine neurons in Parkinson's, it seems like Deprenyl has the ability to protect against the damage of some of these, as well as the effect of aging [3]. > These results suggest that (-)-deprenyl and related compounds may protect neurons from apoptosis and be applicable to delay the deterioration of neurons during advancing ageing and in neurodegenerative disorders. [3] I myself take deprenyl, or its newer cousin azilect for this purpose. It also has the benefit of increasing dopamine and it's a much lower impact focus drug than psychostimulants like amphetamines. [1] http://www.ncbi.nlm.nih.gov/pubmed/3123604 http://www.ncbi.nlm.nih.gov/pubmed/3123604 [2] http://www.ncbi.nlm.nih.gov/pubmed/7669938 http://www.ncbi.nlm.nih.gov/pubmed/7669938 [3] http://www.selegiline.com/apop.html http://www.selegiline.com/apop.html

feld 11y ago
are you doing this as a preventative measure? do you have a history of Parkinsons in your family or something?
- wyldfire 11y ago
  and how old are you?
- willholloway 11y ago
  Yes, completely preventive. I have two family members who developed it in their 70's. I am 30. Update because I can't reply re: self-experimenting: Deprenyl is an incredibly well researched molecule, with a great safety profile. We also have a lot of reason to suspect amphetamines like adderall are neurotoxic to dopamine neurons, and hence my fervent belief that deprenyl should be a first line treatment for those wishing for enhanced focus, and amphetamines should be reserved for tougher cases.
  - feld 11y ago
    Interesting. My dad was diagnosed young, but I don't have any of the Parkinsons markers according to 23andMe My dad has submitted data to 23andMe as well, but unfortunately it didn't come with a free account. It was a special thing they were doing to collect Parkinson's data. So I have no idea if he has the markers.
    - beggi 11y ago
      If you can get the data, you can put it through Promethease.com for $5 and check for markers
  - brianbreslin 11y ago
    I have family members who had it, so I did the 23&me screening for it (negative on genetic mutation thankfully). Have you done that yet?
    - willholloway 11y ago
      I have not done 23&me but really should. My gut feeling is that my family members were perhaps more susceptible than the general population but it was chronic stress & environmental insults that pushed them over the edge, hence the late onset. I have a very strong belief that Parkinson's will be completely cured by the time I could be at risk. It has been completely reversed in several animals with the use of a few different types of stem cells. I have also gotten my hands on a brand new neurogenic small-molecule drug called NSI-189 that is currently undergoing clinical trials. Originally commissioned by DARPA to create the war figher of the future, NSI-189 has shown a robust effect in triggering hippocampal stem cells to regrow the hippocampus. I've ingested about 5 grams and its had a tremendously positive effect on me.
      - biturd 11y ago
        Do you have a diagnosis of something wrong with you, are did you just start taking NSI-189? I was on a medication for 5+ years and it has taken it's tool on me, as well as getting off those meds was not simple. I still struggle with side effects that can take years to go away. What has NSI-189 done for you specifically and how does it make you feel? Are there any annoying side effects and where in the heck did you get it?
stinos 11y ago
the benefit of increasing dopamine Have long term effects of that been researched? I mean, is it healthy to constantly (or however the effects last) and for multiple years have higher dopamine levels than what is natural for a person? Would you still notice the increase in dopamine after years, or would it then be the 'new' normal level?
- biturd 11y ago
  I doubt it, I think it would be much akin to doing cocaine every day. Wasn't L-Dopa more or less pure dopamine, showed promise, and over time lost efficacy? At least, thats how it went in the Robyn Williams movie, which as far as I know was based on a true story and I doubt they would have changed the primary medication name that he discovered was helpful.
biturd 11y ago
If it is all so dopamine related, why don't they just give people dopamine? I take it that it is much more complicated than just dopaminergic reactions at play here?
- jokr004 11y ago
  One big reason is because dopamine does not cross the blood brain barrier... you can't just give it to someone and have it end up in the brain.
- willholloway 11y ago
  Deprenyl works by inhibiting the chemicals in the brain that break down dopamine. The result is higher concentrations. The effect is sustainable.

feld 11y ago

are you doing this as a preventative measure? do you have a history of Parkinsons in your family or something?

wyldfire 11y ago
and how old are you?
willholloway 11y ago
Yes, completely preventive. I have two family members who developed it in their 70's. I am 30. Update because I can't reply re: self-experimenting: Deprenyl is an incredibly well researched molecule, with a great safety profile. We also have a lot of reason to suspect amphetamines like adderall are neurotoxic to dopamine neurons, and hence my fervent belief that deprenyl should be a first line treatment for those wishing for enhanced focus, and amphetamines should be reserved for tougher cases.
- feld 11y ago
  Interesting. My dad was diagnosed young, but I don't have any of the Parkinsons markers according to 23andMe My dad has submitted data to 23andMe as well, but unfortunately it didn't come with a free account. It was a special thing they were doing to collect Parkinson's data. So I have no idea if he has the markers.
  - beggi 11y ago
    If you can get the data, you can put it through Promethease.com for $5 and check for markers
- brianbreslin 11y ago
  I have family members who had it, so I did the 23&me screening for it (negative on genetic mutation thankfully). Have you done that yet?
  - willholloway 11y ago
    I have not done 23&me but really should. My gut feeling is that my family members were perhaps more susceptible than the general population but it was chronic stress & environmental insults that pushed them over the edge, hence the late onset. I have a very strong belief that Parkinson's will be completely cured by the time I could be at risk. It has been completely reversed in several animals with the use of a few different types of stem cells. I have also gotten my hands on a brand new neurogenic small-molecule drug called NSI-189 that is currently undergoing clinical trials. Originally commissioned by DARPA to create the war figher of the future, NSI-189 has shown a robust effect in triggering hippocampal stem cells to regrow the hippocampus. I've ingested about 5 grams and its had a tremendously positive effect on me.
    - biturd 11y ago
      Do you have a diagnosis of something wrong with you, are did you just start taking NSI-189? I was on a medication for 5+ years and it has taken it's tool on me, as well as getting off those meds was not simple. I still struggle with side effects that can take years to go away. What has NSI-189 done for you specifically and how does it make you feel? Are there any annoying side effects and where in the heck did you get it?

stinos 11y ago

the benefit of increasing dopamine Have long term effects of that been researched? I mean, is it healthy to constantly (or however the effects last) and for multiple years have higher dopamine levels than what is natural for a person? Would you still notice the increase in dopamine after years, or would it then be the 'new' normal level?

biturd 11y ago
I doubt it, I think it would be much akin to doing cocaine every day. Wasn't L-Dopa more or less pure dopamine, showed promise, and over time lost efficacy? At least, thats how it went in the Robyn Williams movie, which as far as I know was based on a true story and I doubt they would have changed the primary medication name that he discovered was helpful.

biturd 11y ago

If it is all so dopamine related, why don't they just give people dopamine? I take it that it is much more complicated than just dopaminergic reactions at play here?

jokr004 11y ago
One big reason is because dopamine does not cross the blood brain barrier... you can't just give it to someone and have it end up in the brain.
willholloway 11y ago
Deprenyl works by inhibiting the chemicals in the brain that break down dopamine. The result is higher concentrations. The effect is sustainable.