I think one of the issues with the microscope analogy is that microscopes provide their own light source and the object obstructs the light to produce a signal.

I think one of the issues with the microscope analogy is that microscopes provide their own light source and the object obstructs the light to produce a signal. The objects themselves don't emit light, where as the DNA is assumed to already be emitting sound (vibration) that needs to be amplified.