I use Vispy for a toy project (https://github.com/colour-science/colour-analysis https://github.com/colour-science/colour-analysis) and I'm quite happy with it

I use Vispy for a toy project (https://github.com/colour-science/colour-analysis https://github.com/colour-science/colour-analysis) and I'm quite happy with it so far even though the project is still young. The development team is nice and doing a great job. The API offers different levels of abstraction, I'm mainly using the high level layer which is enough for my current needs and doesn't involve a single glsl line.