Yes definitely adverse effects. 1. My bowel has no idea what is going on half of the time so no routine there. 2. Snoring when I do sleep. This has caused a n

Yes definitely adverse effects. 1. My bowel has no idea what is going on half of the time so no routine there. 2. Snoring when I do sleep. This has caused a number of problems with the wife and neighbours. 3. I can't drink alcohol at all. I end up with a 3 day long hangover even if I have a single beer. Otherwise nothing else. Edit: Just to add a big downside. I had to spend some time in hospital after a physical injury. There is nothing more psychologically damaging than near insomnia immobile in a hospital bed.