You'd have to do what's known as "shorting a stock": http://www.investopedia.com/university/shortselling/shortselling1.asp http://www.investopedia.com/universi

You'd have to do what's known as "shorting a stock": http://www.investopedia.com/university/shortselling/shortselling1.asp http://www.investopedia.com/university/shortselling/shortsel... So pick companies that would be hurt by a real estate bubble (you can look at the previous bubble, and that can include those who hold the debt or secondary sources like companies that sell things to first time home owners like a Home Depo). A secondary strategy might be to invest in companies that focus on rentals since that would go up (I'm assuming you're talking about homes and not commercial real estate): http://investorplace.com/2014/07/rental-reits/#.VZm3J3jsfH0 http://investorplace.com/2014/07/rental-reits/#.VZm3J3jsfH0 Although keep in mind that trying to do a play can come down to timing which can be tricky.