Yep! Also when I don’t want colored output (e.g. when working on familiar codebases or often in the shell), I turn on the Grayscale option in addition to invert

Yep! Also when I don’t want colored output (e.g. when working on familiar codebases or often in the shell), I turn on the Grayscale option in addition to inverted colors. That gives the screen cool retro-futuristic feel, and IMO makes it more aesthetically pleasing. Too bad a shortcut can’t be assigned to this one, but typing "pref access" in Spotlight gets the relevant settings page. As a related tip, on iOS you can have a home button triple-press shortcut which you can assign inverted colors or grayscale, or both. Was stoked when discovered that.