There's likely very little adapting to do. What doesn't work is expecting to live in microgravity long term, and then come back to gravity. There's no talk what

There's likely very little adapting to do. What doesn't work is expecting to live in microgravity long term, and then come back to gravity. There's no talk whatsoever about what happens if you never go back to gravity. Until they allow a volunteer astronaut to spend the rest of their life in space without returning, we won't have a real-world analysis of what happens to one's body as they age. And of course the truly interesting experiment: a child born in space, who spends their entire life there. Of course, "child abuse" means this will not happen in our lifetimes. Let alone seeing what 2-3 generations of space-bound life results in.