I'd like to point out that large-memory/many-core multi-user machines are very much alive in Computational Science (Computational Physics, Computational Chemist

I'd like to point out that large-memory/many-core multi-user machines are very much alive in Computational Science (Computational Physics, Computational Chemistry, etc). Usually as test-beds (before deploying on clusters), visualisation system, or simply front-end nodes for clusters.