3 ms·
That's very interesting, especially combined with data showing that SSRIs in fact decrease brain serotonin over the long term [1]. We truly do not understand th
by ksenzee 11y ago
That's very interesting, especially combined with data showing that SSRIs in fact decrease brain serotonin over the long term [1]. We truly do not understand the mechanism of action for these drugs.
[1] https://www.psychologytoday.com/blog/mad-in-america/201011/new-rat-study-ssris-markedly-deplete-brain-serotonin https://www.psychologytoday.com/blog/mad-in-america/201011/n...
- eivarv 11y agoIsn't it more that we don't understand why it works (i.e. what kind of connection serotonin has with these mental illnesses) rather than the mechanism of action itself, which is believed to be serotonin staying longer in the synaptic cleft by way of inhibiting reuptake, leading to repeated stimulation of the post-synaptic receptors? I was under the impression that SSRI's were specifically designed to target the serotonin system.