5 ms·

The paper in Cell Metabolism is here: http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00224-7 http://www.cell.com/cell-metabolism/abstract/S1550-4131

The paper in Cell Metabolism is here: http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00224-7 http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)0...

zdw 11y ago
Contents of the diet are on this PDF: http://www.cell.com/cell-metabolism/pdfExtended/S1550-4131(15)00224-7 http://www.cell.com/cell-metabolism/pdfExtended/S1550-4131(1... The human fasting mimicking diet (FMD) program is a plant-based diet program designed to attain fasting-like effects while providing micronutrient nourishment (vitamins, minerals, etc.) and minimize the burden of fasting. It comprises proprietary vegetable-based soups, energy bars, energy drinks, chip snacks, chamomile flower tea, and a vegetable supplement formula tablet. The human FMD diet consists of a 5 day regimen: day 1 of the diet supplies ~1,090 kcal (10% protein, 56% fat, 34% carbohydrate), days 2–5 are identical in formulation and provide 725 kcal (9% protein, 44% fat, 47% carbohydrate).
- deleted 11y ago
  [deleted]
- bradleyjg 11y ago
  It doesn't seem like the study can be replicated with that little information, and the word "proprietary" is especially worrying on that account.
  - ivanhoe 11y ago
    They'll brand it and sell it, it's obviously the plan. Now question is if this is really any better than all the other intermittent fasting technics, since they all describe pretty much the same benefits, but it's (for now) hard to quantify and compare the results and the risks...
    - gwern 11y ago
      And they didn't include a direct comparison to more common IF: the control in the mice and human was both one's normal diet. So the exact causal claim established a little ambiguous.
- themgt 11y ago
  It really shouldn't be allowed to publish science without the underlying data regarding what you did - barely any of that list gives much hint as to actual ingredients. That said, this conforms to a lot of previous research regarding fasting, and so it's a reasonable assumption that if you did a once-monthly 5 day fast at 33% of normal calorie intake, composed of a mix of nutrient/vitamin-dense plants and herbs, you would see similar benefits. In reality this should just be your normal diet - eat lots of plants, add a reasonable amount of healthy meat (i.e. not a kilo of red meat a day). Limit simple carbohydrates, especially sugar. Keep calories reasonably low (which will happen naturally because you'll feel full & satisfied).
  - bjt 11y ago
    > In reality this should just be your normal diet Maybe the proportions, but not the total amounts. 725 calories per day is way too low on a long term basis.
    - themgt 11y ago
      Completely agreed - I do think the fasting studies suggest you should find some way to integrate that into your diet, and the easiest way is likely intermittently, trying to space out and decrease your eating in reasonable ways, e.g. taking consistent 12-20 hour breaks between large meals, spending a few days a month on a 1/3 normal caloric intake, etc. You don't need to keep yourself in a low-calorie state, but it's important to enter that state to some degree, on some number of occasions, to get your body to kick off the internal processes of autophagy and renewal that result in a variety of benefits, to healthspan even moreso than lifespan.
  - chisleu 11y ago
    There are websites that let you put in your macros and your calories, and the type of diet you want to eat, and they design a diet for you automatically.

The paper in Cell Metabolism is here: http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00224-7 http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)0...

zdw 11y ago

Contents of the diet are on this PDF: http://www.cell.com/cell-metabolism/pdfExtended/S1550-4131(15)00224-7 http://www.cell.com/cell-metabolism/pdfExtended/S1550-4131(1... The human fasting mimicking diet (FMD) program is a plant-based diet program designed to attain fasting-like effects while providing micronutrient nourishment (vitamins, minerals, etc.) and minimize the burden of fasting. It comprises proprietary vegetable-based soups, energy bars, energy drinks, chip snacks, chamomile flower tea, and a vegetable supplement formula tablet. The human FMD diet consists of a 5 day regimen: day 1 of the diet supplies ~1,090 kcal (10% protein, 56% fat, 34% carbohydrate), days 2–5 are identical in formulation and provide 725 kcal (9% protein, 44% fat, 47% carbohydrate).

deleted 11y ago
[deleted]
bradleyjg 11y ago
It doesn't seem like the study can be replicated with that little information, and the word "proprietary" is especially worrying on that account.
- ivanhoe 11y ago
  They'll brand it and sell it, it's obviously the plan. Now question is if this is really any better than all the other intermittent fasting technics, since they all describe pretty much the same benefits, but it's (for now) hard to quantify and compare the results and the risks...
  - gwern 11y ago
    And they didn't include a direct comparison to more common IF: the control in the mice and human was both one's normal diet. So the exact causal claim established a little ambiguous.
themgt 11y ago
It really shouldn't be allowed to publish science without the underlying data regarding what you did - barely any of that list gives much hint as to actual ingredients. That said, this conforms to a lot of previous research regarding fasting, and so it's a reasonable assumption that if you did a once-monthly 5 day fast at 33% of normal calorie intake, composed of a mix of nutrient/vitamin-dense plants and herbs, you would see similar benefits. In reality this should just be your normal diet - eat lots of plants, add a reasonable amount of healthy meat (i.e. not a kilo of red meat a day). Limit simple carbohydrates, especially sugar. Keep calories reasonably low (which will happen naturally because you'll feel full & satisfied).
- bjt 11y ago
  > In reality this should just be your normal diet Maybe the proportions, but not the total amounts. 725 calories per day is way too low on a long term basis.
  - themgt 11y ago
    Completely agreed - I do think the fasting studies suggest you should find some way to integrate that into your diet, and the easiest way is likely intermittently, trying to space out and decrease your eating in reasonable ways, e.g. taking consistent 12-20 hour breaks between large meals, spending a few days a month on a 1/3 normal caloric intake, etc. You don't need to keep yourself in a low-calorie state, but it's important to enter that state to some degree, on some number of occasions, to get your body to kick off the internal processes of autophagy and renewal that result in a variety of benefits, to healthspan even moreso than lifespan.
- chisleu 11y ago
  There are websites that let you put in your macros and your calories, and the type of diet you want to eat, and they design a diet for you automatically.