4 ms·

Despite three randomized trials, "there is no evidence that these persistent subjective complaints represent ongoing active infection or that repeated or prolon

Despite three randomized trials, "there is no evidence that these persistent subjective complaints represent ongoing active infection or that repeated or prolonged courses of antibiotics ... provide any benefit." [paywall] http://www.uptodate.com/contents/clinical-manifestations-of-lyme-disease-in-adults?source=machineLearning&search=lyme+disease&selectedTitle=1~150&sectionRank=1&anchor=H21#H21 http://www.uptodate.com/contents/clinical-manifestations-of-... http://www.ncbi.nlm.nih.gov/pubmed?term=11450676 http://www.ncbi.nlm.nih.gov/pubmed?term=11450676 N Engl J Med. 2001 Jul 12;345(2):85-92. Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease. Klempner MS1, Hu LT, Evans J, Schmid CH, Johnson GM, Trevino RP, Norton D, Levy L, Wall D, McCall J, Kosinski M, Weinstein A. http://www.ncbi.nlm.nih.gov/pubmed?term=12821734 http://www.ncbi.nlm.nih.gov/pubmed?term=12821734 Study and treatment of post Lyme disease (STOP-LD): a randomized double masked clinical trial. Krupp LB, Hyman LG, Grimson R, Coyle PK, Melville P, Ahnn S, Dattwyler R, Chandler B Neurology. 2003;60(12):1923. http://www.ncbi.nlm.nih.gov/pubmed?term=17928580 http://www.ncbi.nlm.nih.gov/pubmed?term=17928580 Neurology. 2008 Mar 25;70(13):992-1003. Epub 2007 Oct 10. A randomized, placebo-controlled trial of repeated IV antibiotic therapy for Lyme encephalopathy. Fallon BA1, Keilp JG, Corbera KM, Petkova E, Britton CB, Dwyer E, Slavov I, Cheng J, Dobkin J, Nelson DR, Sackeim HA.

scott_s 11y ago
I believe those are different from the submitted article. The submitted article interviews a man who was never diagnosed or treated for Lyme disease until 20 years after he contracted it. After he was treated, his symptoms went away. (Except for his heart issues, which were permanent because over the course of the disease, his heart had developed significant scar tissue.) Those studies are about people who have been diagnosed, treated, and then continue to experience symptoms. The background from the first paper: It is controversial whether prolonged antibiotic treatment is effective for patients in whom symptoms persist after the recommended antibiotic treatment for acute Lyme disease. Lyme disease is real and uncontroversial. What is controversial is that if there is such a thing as a chronic Lyme disease that persists after the initial antibiotic treatment. The current scientific evidence is against such a thing.

scott_s 11y ago

I believe those are different from the submitted article. The submitted article interviews a man who was never diagnosed or treated for Lyme disease until 20 years after he contracted it. After he was treated, his symptoms went away. (Except for his heart issues, which were permanent because over the course of the disease, his heart had developed significant scar tissue.) Those studies are about people who have been diagnosed, treated, and then continue to experience symptoms. The background from the first paper: It is controversial whether prolonged antibiotic treatment is effective for patients in whom symptoms persist after the recommended antibiotic treatment for acute Lyme disease. Lyme disease is real and uncontroversial. What is controversial is that if there is such a thing as a chronic Lyme disease that persists after the initial antibiotic treatment. The current scientific evidence is against such a thing.