Like all things its nature vs nurture. There are plenty of historical accounts of people being anti-social agoraphobes or autistic in the past. They were either

Like all things its nature vs nurture. There are plenty of historical accounts of people being anti-social agoraphobes or autistic in the past. They were either labeled 'eccentric' if they were rich or crazy if they weren't. "Demon possession" during bible days was likely a form of mental illness, and those who genuinely heard "God" might have either been on psychedelics or had genuine conditions (schizophrenia comes to mind).