You don't need to be a physicist: if the panel is sealed there will be a constant pressure inside. The pressure on each face is then P_ext-P_int. It's just as l

You don't need to be a physicist: if the panel is sealed there will be a constant pressure inside. The pressure on each face is then P_ext-P_int. It's just as likely that both panels will fail at the same time in that case as in the case with a hole; but the bonus in this case is that you can set up the internal pressure so both panels have lower nominal pressure (but the internal at least should be able to still handle the full pressure difference). I know it's routine to manufacture even household glass panels with different gases sealed in their interior (I think they put Argon inside? some low conductivity gas), but afaik it's at atmospheric pressure.