Meat of the Conclusions section: >To date and according to the clinical trials conducted so far, it is becoming evident that RES exerts cardioprotective benefi

Meat of the Conclusions section: >To date and according to the clinical trials conducted so far, it is becoming evident that RES exerts cardioprotective benefits through the improvement of inflammatory markers, atherogenic profile, glucose metabolism and endothelial function (Table ​22). These effects have been observed using both high and low doses of RES and both in healthy volunteers and medicated patients. However, the specific mechanisms by which this may occur are not yet clear. More trials are needed to confirm these and other possible effects and mechanisms. The promising neurodegenerative and cancer chemopreventive effects of RES in animal models have not been yet confirmed in humans. There follows quite about about what is not known, esp. about mechanisms.