3 ms·

Does SENS get NIA funding? Have they put forward any candidates to NIA's ITP?

• reasonattlm 11y ago
  SENS and SENS-like work outside the area of cancer and stem cell research is generally at the pre-animal-testing stage, so not something you can run via the ITP. Senescent cell clearance is there, so could be making in that direction in the years ahead. Nothing moves fast of course. I'm not sure where the ITP stands on things like stem cell treatments. They are very focused on diet, drugs, supplements, and resulting complex changes in the operation of normal metabolism. i.e. things that don't matter if you want meaningful results in extended healthy life. Good for scientific rigor though, going back through all the studies in the past that failed to control for inadvertent calorie restriction and showing that they were wrong.
  • xaa 11y ago
    Well, they don't allow interventions that require daily injections, etc, but the implication seems to be that something that requires a once-a-month injection, such as senescent cell clearance, would likely be allowed. Some of the "senolytics" are small molecules as well (Jim Kirkland's work, for example). Actually the ITP is not just interested in metabolism. They do hormones and anti-inflammatories as well. But I don't get the impression that they're solely focused on those things: anyone who can make a good case for a non-labor-intensive intervention can get in. That's why I asked if SENS has applied to the ITP: because I know they have some different ideas than academia, but I'd like to know more about specific interventions they've proposed or tested. Are you by chance going to the AAA meeting in Marina del Rey in a few weeks? I'd buy you a beer there and we could continue the conversation then ;)