3 ms·
I actually spoke with one of the principals at the company last weekend. I'm still not entirely sure it's a real effect, but he was telling me that they have mo
by entee 11y ago
I actually spoke with one of the principals at the company last weekend. I'm still not entirely sure it's a real effect, but he was telling me that they have mouse models that are incredibly impressive. That said, cancer has been cured in mice many, many times.
The general idea is that if you prevent fatty acid radicals from arising in the first place, you radically improve cellular health. They argue that all sorts of things go wrong in a cell, but that the final reason a cell will die is because it loses the ability to cope with reactive species.
Fats are one major source of radicals, because once you get one radical, generating the next radical is an auto-catalytic event. That means one radical generates dozens of others. If you can prevent that single radical, you therefore have a huge impact, and deuterated are absolutely a way to reduce radical formation.
2 things on cost: because there is a single bond in the fats they are targeting that is far more likely to form a radical than the others, you only need a single position to be deuterated to have the effect. The principal's claim was that cost of deuterium was incredibly low, and that everything about the chemistry was scalable. He fully expected that the doses could be made at an affordable price point.
Like I said, it may not pan out, but it did sound worth pursuing. That safety study will also likely test efficacy to a certain extent (common in rare disease research). Could be pretty cool if it works!