Compiler optimization is obviously a sleeping field currently. There's nothing that's made it into practical compilers to address the bottlenecks shifting from

Compiler optimization is obviously a sleeping field currently. There's nothing that's made it into practical compilers to address the bottlenecks shifting from ALU work to data storage and layout considerations. Consider all the gnashing of teeth and wringing of hands that goes on in C++ circles about inefficient data layout & representation by inferior programmers, and the stories of victorious manual data layout refactorings by performance heroes. DJB's slides don't address the data side because he only does crypto, and that's one of the fields where the ALU twiddling is still relevant. But crypto is also rarely a bottleneck.