Not that I'm recommending anyone come remotely close to risking an acetaminophen overdose — or that if they do end up overdosing, they try to treat it themselve

Not that I'm recommending anyone come remotely close to risking an acetaminophen overdose — or that if they do end up overdosing, they try to treat it themselves — but the dietary supplement N-Acetyl Cysteine is a first-line treatment for acetaminophen poisoning. It appears to work equally well whether it's taken orally or intravenously, though the oral course takes longer and prevents the concurrent use of activated charcoal to limit the body's absorption of the drug.