Another option is of course Salesforce/Force.com. Point and click, incredible customization potential, easy to build UI and reports, point-and-click business pr

Another option is of course Salesforce/Force.com. Point and click, incredible customization potential, easy to build UI and reports, point-and-click business processes, and very extensible by code if your admins can't accomplish something. Still very expensive, but free for non-profits!