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Melatonin and DHEA are hormones and are OTC. But just because they're OTC doesn't mean they should be taken lightly. Hormones are highly regulated in our bodies
by driverdan 12y ago
Melatonin and DHEA are hormones and are OTC. But just because they're OTC doesn't mean they should be taken lightly. Hormones are highly regulated in our bodies and taking extra can cause decreased natural production.
Adrafinil is not OTC, it is unregulated. That means you can sell it in the "research chemical" grey market but not as a drug.
- hashmymustache 12y agoYou have to distinguish hormonal regulatory mechanisms that are externally vs internally triggered if you're going to discuss decreased natural synthesis. Oral testosterone? Pituitary measures it and says to the testicles, "we're good here" and testicles atrophy. Oral prednisone? Pituitary says to adrenals "we're good" and adrenals shut down cortisol production. Melatonin, however, is externally regulated through blue light suppression. So taking it doesn't engage any feedback inhibition, it just increases blood concentration.
- gnaritas 12y ago> Hormones are highly regulated in our bodies and taking extra can cause decreased natural production. Normally true, but that doesn't apply to melatonin, it has no such down regulation mechanism.