I'm a PhD student in operations research interesting in working for a company addressing a global problem via an approach with low probability of success but hi

I'm a PhD student in operations research interesting in working for a company addressing a global problem via an approach with low probability of success but high expected value. Think Helion, Ambri, Firefly (the rockets), Planetary Resources, Immunity Project, etc. The thought being any one of these companies will likely fail, but if 5% of them succeed, that's hugely beneficial for society. What advice can you give?